Biological Effect, Aquation, and Kinetics of Oxidation of Bis(2-aminobenzothiazole)dichlorocobalt(II) Complex by Periodate in Aqueous Acidic Medium


  • Alaa Eldin Mokhtar Abdel-Hady

    Corresponding author
    • Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sinai University, Arish City, Cairo, Egypt
    Search for more papers by this author

Correspondence to: Alaa Eldin Mokhtar Abdel-Hady; e-mail:


The biological effect, aquation, and kinetics of oxidation of bis(2-aminobenzothiazole)dichlorocobalt(II) complex by periodate in aqueous acidic solutions were studied. The complex exhibited a broad resistance toward the studied pathogens. The average value of the aquation constant was calculated spectrophotometrically as 2.55 × 10−5 mol2 dm−6. Kinetics of the oxidation reaction showed first-order dependence on each reactant concentration and increased by increasing pH over the 3.80–4.80 range, 35–50°C, and decreased by increasing the ionic strength over the 0.1–0.5 mol dm−3 range. The polymerization of acrylonitrile was taken as an evidence for an inner-sphere mechanism through the formation of free radical intermediates of Co(III) complexes, which were slowly converted to the final Co(III)products.