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Biological Effect, Aquation, and Kinetics of Oxidation of Bis(2-aminobenzothiazole)dichlorocobalt(II) Complex by Periodate in Aqueous Acidic Medium

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  • Alaa Eldin Mokhtar Abdel-Hady

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    • Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sinai University, Arish City, Cairo, Egypt
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Correspondence to: Alaa Eldin Mokhtar Abdel-Hady; e-mail: alaaeldin60@yahoo.com.

ABSTRACT

The biological effect, aquation, and kinetics of oxidation of bis(2-aminobenzothiazole)dichlorocobalt(II) complex by periodate in aqueous acidic solutions were studied. The complex exhibited a broad resistance toward the studied pathogens. The average value of the aquation constant was calculated spectrophotometrically as 2.55 × 10−5 mol2 dm−6. Kinetics of the oxidation reaction showed first-order dependence on each reactant concentration and increased by increasing pH over the 3.80–4.80 range, 35–50°C, and decreased by increasing the ionic strength over the 0.1–0.5 mol dm−3 range. The polymerization of acrylonitrile was taken as an evidence for an inner-sphere mechanism through the formation of free radical intermediates of Co(III) complexes, which were slowly converted to the final Co(III)products.

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