Kinetics of Hydrolysis of Bisoprolol Hemifumarate in Aqueous Acidic Solutions


Correspondence to: Mateusz Szalka; email:


The kinetics of hydrolysis of bisoprolol hemifumarate in acidic conditions was studied using high-performance liquid chromatography. For this purpose, different hydrohalic acids and one weak carboxylic acid were used. The rate constants, the order of the reaction, and the activation parameters: enthalpy, entropy, and energy of activation were calculated. A proposition for the mechanism of degradation was provided.