Presented at the Triological Society Meeting May 1–4, 2008. Orlando, Florida, U.S.A.
Transforming growth factor-β1 shows an incremental osteoinductive dose-response relationship†
Article first published online: 31 DEC 2008
Copyright © 2009 The American Laryngological, Rhinological, and Otological Society, Inc.
Volume 119, Issue 1, pages 126–130, January 2009
How to Cite
Moxham, J. P., Wong, K. K. and Kibblewhite, D. J. (2009), Transforming growth factor-β1 shows an incremental osteoinductive dose-response relationship. The Laryngoscope, 119: 126–130. doi: 10.1002/lary.20009
- Issue published online: 31 DEC 2008
- Article first published online: 31 DEC 2008
- Manuscript Accepted: 29 SEP 2008
- Transforming growth factor-β;
To determine if there is a dose–response curve for TGF-β1 in a rabbit calvarial defect model.
Controlled animal study using arms of increasing concentrations of TGF-β1 to evaluate the osteoinductive potential of each arm.
Sixteen skeletally mature New Zealand white rabbits were randomized into control and experimental arms. Incremental doses of TGF-β1 delivered in an inactivated guanidine-extracted demineralized bone matrix (Gu-DBM) carrier were implanted into a critically sized calvarial defect. The animals were sacrificed at 4 weeks and histomorphometric analysis was then accomplished.
TGF-β1 showed a dose–response relationship, with the higher doses chosen for this study causing more robust osteoinduction.
In this pilot dosing study, TGF-β1 demonstrates increasing osteoinduction with increasing dose levels in this animal model. Laryngoscope, 119:126–130, 2009