IgE response to staphylococcal enterotoxins in adenoid tissues from atopic children
Article first published online: 31 DEC 2008
Copyright © 2009 The American Laryngological, Rhinological, and Otological Society, Inc.
Volume 119, Issue 1, pages 171–175, January 2009
How to Cite
Shin, S.-Y., Choi, G.-S., Lee, K.-H., Kim, S.-W., Cho, J.-S. and Park, H.-S. (2009), IgE response to staphylococcal enterotoxins in adenoid tissues from atopic children. The Laryngoscope, 119: 171–175. doi: 10.1002/lary.20046
- Issue published online: 31 DEC 2008
- Article first published online: 31 DEC 2008
- Manuscript Accepted: 15 JUL 2008
- Korea Health 21 R&D Project
- Ministry of Health & Welfare, Republic of Korea. Grant Numbers: A030001, A050571
- Staphylococcal superantigen;
- mast cell
To evaluate local production of staphylococcal superantigen (SAg)-specific IgE in adenoid tissue and to compare its prevalence with that in the tonsil and serum, as well as its relationship with markers of allergic inflammation within adenoid tissue.
Prospective randomized study.
We recruited 18 atopic children who had rhinitis symptoms and were sensitized to more than one common aeroallergen, and 22 nonatopic children undergoing adenotonsillectomy. Immunoassays were performed using adenoid tissue homogenate to quantify the levels of three staphylococcal SAg-specific IgE (SEA, SEB, and TSST-1), total IgE, eosinophil cationic protein (ECP), mast cell tryptase, and soluble CD23.
Three kinds of SAg-specific IgE were detected in the adenoid and tonsil tissues of atopic patients, but not in those of nonatopic patients. In atopic children, the prevalence of SEA-, SEB-, and TSST-1-specific IgE in adenoid tissues (61.1%, 27.8%, 33.3%, respectively) were higher than those in tonsil tissues (38.9%, 5.6%, 11.1%, respectively) and in sera (11.1%, 27.8%, 16.7%, respectively). Subjects with high SEA levels showed significantly higher serum and adenoid total IgE, with higher eosinophilia. Significant correlations were noted between SAg-specific IgE levels and tryptase levels in adenoid tissue.
Local specific IgE response to staphylococcal SAgs, especially SEA may contribute to ongoing allergic inflammation in adenoid tissue from atopic children. Laryngoscope, 119:171–175, 2009