Vocal fold augmentation with calcium hydroxylapatite: Twelve-month report
Article first published online: 9 MAR 2009
Copyright © 2009 The American Laryngological, Rhinological, and Otological Society, Inc.
Volume 119, Issue 5, pages 1033–1041, May 2009
How to Cite
Rosen, C. A., Gartner-Schmidt, J., Casiano, R., Anderson, T. D., Johnson, F., Remacle, M., Sataloff, R. T., Abitbol, J., Shaw, G., Archer, S. and Zraick, R. I. (2009), Vocal fold augmentation with calcium hydroxylapatite: Twelve-month report. The Laryngoscope, 119: 1033–1041. doi: 10.1002/lary.20126
- Issue published online: 20 APR 2009
- Article first published online: 9 MAR 2009
- Manuscript Accepted: 21 NOV 2008
- General otolaryngology;
- head and neck;
- quality of life;
To evaluate the long-term effectiveness of calcium hydroxylapatite (CaHA) vocal fold injection for patients with glottal insufficiency.
Multicenter, open-label, prospective clinical study of CaHA vocal fold injection.
Each patient served as his/her own control. Voice-related outcome measures were collected for pre-injection, 1, 3, 6, and 12 months.
Sixty-three patients were available for evaluation. Fifty-three percent of the injection procedures were done in the office. Fifty-seven percent of patients were diagnosed with unilateral paralysis and 43% with glottal incompetence with mobile vocal folds. Patient satisfaction 12 months after injection showed 67% reporting a significant improvement in voice and 81% reporting at least a moderate improvement in voice. Utilizing the Voice Handicap Index–10, visual analog scale (vocal effort), Consensus Assessment Perceptual Evaluation V (judgments of voice severity), and objective voice measures of glottal closure (maximum phonation time and S:Z ratio), paired t tests showed significant improvements after treatment. A 22% further treatment rate was found at the 12-month time point.
One-year results in this large cohort of patients with glottal incompetence treated with CaHA vocal fold injection demonstrate that excellent clinical results were achieved. Laryngoscope, 2009