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IgE-mediated fungal allergy in allergic fungal sinusitis

Authors

  • Harshita Pant FRACS, PhD,

    Corresponding author
    1. Department of Otorhinolaryngology Head and Neck Surgery, the University of Adelaide, Adelaide, Australia and Flinders University, Bedford Park, Australia
    • Clinical Instructor, Fellow – Rhinology & Skull Base Surgery, University of Pittsburgh Physicians, UPMC Department of Otorhinolaryngology, Head & Neck Surgery Eye and Ear Institute, Suite 500 200 Lothrop Street, Pittsburgh, PA 15213

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  • Mark A. Schembri FRACS,

    1. Department of Otorhinolaryngology Head and Neck Surgery, Royal Adelaide Hospital, Adelaide, Australia
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  • Peter J. Wormald FRACS, MD,

    1. Department of Otorhinolaryngology Head and Neck Surgery, the University of Adelaide, Adelaide, Australia and Flinders University, Bedford Park, Australia
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  • Peter J. Macardle PhD

    1. Department of Immunology, Arthritis and Allergy, Flinders Medical Centre and Flinders University, Bedford Park, Australia
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Abstract

This review will address the current knowledge of the pathogenic mechanisms in allergic fungal sinusitis (AFS) and the basis for the current classification of a subgroup of chronic rhinosinusitis patients. Special attention is directed to the role of immunoglobulin E (IgE)-mediated fungal allergy in the pathogenesis of AFS. Concepts relating to the mucosal inflammatory response are introduced, as a knowledge of the reactions of the sinus mucosal cells can lead to a better understanding of the mechanisms perpetuating and maintaining the chronic inflammation. Laryngoscope, 2009

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