Head and Neck

Radiation therapy for minor salivary gland carcinoma†

  1. Marco Cianchetti MD2,
  2. Pamela S. Sandow DMD1,
  3. Lauren D. Scarborough BS1,
  4. Christopher G. Morris MS2,
  5. Jessica Kirwan MA2,
  6. John W. Werning MD3,
  7. William M. Mendenhall MD2,*

Article first published online: 8 JUN 2009

DOI: 10.1002/lary.20501

Issue

The Laryngoscope

The Laryngoscope

Volume 119, Issue 7, pages 1334–1338, July 2009

Additional Information

How to Cite

Cianchetti, M., Sandow, P. S., Scarborough, L. D., Morris, C. G., Kirwan, J., Werning, J. W. and Mendenhall, W. M. (2009), Radiation therapy for minor salivary gland carcinoma. The Laryngoscope, 119: 1334–1338. doi: 10.1002/lary.20501

Author Information

  1. 1

    College of Dentistry, College of Medicine, University of Florida, Gainesville, Florida, U.S.A.

  2. 2

    Department of Radiation Oncology, College of Medicine, University of Florida, Gainesville, Florida, U.S.A.

  3. 3

    Department of Otolaryngology, College of Medicine, University of Florida, Gainesville, Florida, U.S.A.

*2000 SW Archer Rd., PO Box 100385, Gainesville, FL 32610-0385

  1. †

    The authors have no conflicts of interest to disclose.

Publication History

  1. Issue published online: 23 JUN 2009
  2. Article first published online: 8 JUN 2009
  3. Manuscript Accepted: 20 MAR 2009

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Keywords:

  • Minor salivary gland carcinoma;
  • radiotherapy;
  • surgery

Abstract

Objectives/Hypothesis:

To analyze the outcomes of patients treated for minor salivary gland carcinoma with radiotherapy (RT), either alone or combined with surgery.

Study Design:

Retrospective review.

Methods:

Between September 1966 and December 2006, 140 patients were treated with curative intent at our institution for previously untreated minor salivary gland carcinomas (RT alone, 64 patients; combined RT and surgery, 76 patients). Median follow-up for all patients was 5.5 years.

Results:

The 10-year local control rate was 66%, and multivariate analysis revealed that treatment group (P = .0004) and T stage (P = .0001) significantly influenced this endpoint. Patients treated with RT alone had a lower local control rate than patients treated with RT and surgery. The 10-year local-regional control rate was 61%, and multivariate analysis revealed that treatment group (P = .0174), overall stage (P = .0004), and N stage (P = .0492) significantly influenced this endpoint. The 10-year distant metastasis-free survival rate was 67%, and multivariate analysis revealed that overall stage (P = .0016) significantly influenced this endpoint. The 10-year cause-specific survival rate was 56%, and multivariate analysis revealed that overall stage (P < .0001) significantly influenced this endpoint. The 10-year overall survival rate was 45%, and multivariate analysis revealed that overall stage (P = .0047), N stage (P = .0173), and nerve invasion (P = .0409) significantly influenced this endpoint.

Conclusions:

Most patients with minor salivary gland carcinoma were cured with RT alone or combined with surgery. Treatment group, T stage, and overall stage significantly influenced the probability of cure. Patients treated with combined surgery and RT had a better prognosis, perhaps due in part to selection bias. Laryngoscope, 2009

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