This study was supported by an endowment in support of the Barry Baker Laboratory of Head and Neck Oncology, the Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation, and an Ingram Professorship in Cancer Research.
Head and Neck
Human papillomavirus in early laryngeal carcinoma†
Version of Record online: 1 JUN 2009
Copyright © 2009 The American Laryngological, Rhinological, and Otological Society, Inc.
Volume 119, Issue 8, pages 1531–1537, August 2009
How to Cite
Baumann, J. L., Cohen, S., Evjen, A. N., Law, J. H., Vadivelu, S., Attia, A., Schindler, J. S., Chung, C. H., Wirth, P. S., Meijer, C. J.L.M., Snijders, P. J.F., Yarbrough, W. G. and Slebos, R. J.C. (2009), Human papillomavirus in early laryngeal carcinoma. The Laryngoscope, 119: 1531–1537. doi: 10.1002/lary.20509
- Issue online: 21 JUL 2009
- Version of Record online: 1 JUN 2009
- Manuscript Accepted: 26 MAR 2009
- Human papilloma virus;
- larynx carcinoma;
- carcinoma in situ;
- head and neck squamous cell carcinoma
To examine the role of HPV status in the etiology, prognosis, and treatment of head and neck squamous cell carcinoma in early larynx malignancies.
Thirty-eight cases of T1 or carcinoma in situ (CIS) laryngeal lesions were examined for the presence of human papilloma virus (HPV) using an inclusive polymerase chain reaction (PCR)/hybridization technique capable of identifying 37 HPV subtypes.
HPV DNA was detected in 6 (16%) of the 38 lesions, representing HPV types 16, 26, 31, 39, and 52, and p16 tumor suppressor protein expression was confirmed in 10 representative cases. This HPV prevalence is higher than that noted in many previous laryngeal cancer studies, possibly due to the relatively large panel of subtypes screened for in this study. Identification of HPV-26, which has been associated with uterine cervical cancer, in an early laryngeal cancer specimen represents the first evidence of this subtype in a laryngeal carcinoma. Consistent with reports focusing on head and neck squamous cell carcinoma (HNSCC) arising from other subsites within the upper aerodigestive tract, patients with HPV-positive laryngeal carcinomas were of younger age and were somewhat less likely to have a history of tobacco use, although the latter of the two findings did not reach statistical significance.
Our findings emphasize the presence of a broad spectrum of HPV types in a relevant proportion of early laryngeal cancers, and together with evidence of an association of HPV tumor status with a more favorable clinical course, provide a rationale for the routine HPV testing of small larynx lesions. Laryngoscope, 2009