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Keywords:

  • Blood-labyrinth barrier;
  • sensorineural hearing loss;
  • brain-derived nerve stimulating factor;
  • neurotrophins;
  • cisplatin

Abstract

Objectives/Hypothesis:

A possible medical treatment for sensorineural hearing loss using brain-derived nerve growth factor (BDNF) was explored. The hypothesis is that direct intracochlear application of BDNF will result in improved hearing.

Study Design:

Animal research study.

Methods:

Significant hearing loss was created using cisplatin in 11 guinea pigs. One month later, bilateral cochleostomies were performed placing 0.05 μg of BDNF in one cochlea of each animal prior to plugging with connective tissue. The other cochlea served as a control. Auditory brain-stem response (ABR) testing was then carried out for three months at 6,000, 8,000, 12,000, and 24,000 Hz.

Results:

ABR thresholds were better in the treated ear for all frequencies. Threshold differences were statistically significantly better two months after treatment (general linear model, repeated measures P = .045).

Conclusions:

Intracochlear application of BDNF may prevent hearing loss. Laryngoscope, 2009