Presented for the American Broncho-Esophagological Association (ABEA), Combined Otolaryngology Spring Meeting, Orlando, Florida, U.S.A., May 1–4, 2008.
Version of Record online: 24 JUN 2009
Copyright © 2009 The American Laryngological, Rhinological, and Otological Society, Inc.
Volume 119, Issue 9, pages 1844–1847, September 2009
How to Cite
Halum, S. L., Sycamore, D. L. and McRae, B. R. (2009), A new treatment option for laryngeal sensory neuropathy. The Laryngoscope, 119: 1844–1847. doi: 10.1002/lary.20553
This study was supported in part by a National Institutes of Health/National Institute on Deafness and Other Communication Disorders (NIH/NIDCD) T32 training grant. None of the authors has any financial disclosures pertaining to this study.
- Issue online: 27 AUG 2009
- Version of Record online: 24 JUN 2009
- Manuscript Accepted: 30 APR 2009
- Laryngeal sensory neuropathy;
- vagal neuropathy;
Laryngeal sensory neuropathy (LSN) may produce a variety of symptoms, including chronic cough, globus sensation, odynophonia, and/or odynophagia. Etiologies are often iatrogenic, viral, or idiopathic, although the diagnosis is generally one of exclusion. The aim of this study is to introduce pregabalin (Lyrica, Pfizer Inc., New York, NY) as a potential new therapy for LSN.
Retrospective clinical investigation.
Charts were reviewed from 12 consecutive patients who were prescribed pregabalin for symptoms of LSN. Outcomes were reviewed by analyzing pre and post-treatment questionnaires asking patients to rate symptoms on a scale from 0 to 5. Adverse effects and evidence of drug tolerance were also recorded.
Two patients did not tolerate pregabalin due to somnolence. Of those that tolerated the medication, mean pretreatment chief complaint symptom severity rating was 3.9, whereas mean post-treatment symptom rating was 1.2 after 1 month of pregabalin therapy. None of the patients developed drug tolerance effects over time.
Pregabalin therapy appears to be an effective treatment option for laryngeal sensory neuropathy. Future prospective studies are needed to compare outcomes between pregabalin and other medications as treatments for LSN. Laryngoscope, 2009