Sinonasal

Hereditary hemorrhagic telangiectasia/avastin

  1. Terence M. Davidson MD1,*,
  2. Scott E. Olitsky MD2,
  3. Julie L. Wei MD3

Article first published online: 8 DEC 2009

DOI: 10.1002/lary.20757

Issue

The Laryngoscope

The Laryngoscope

Volume 120, Issue 2, pages 432–435, February 2010

Additional Information

How to Cite

Davidson, T. M., Olitsky, S. E. and Wei, J. L. (2010), Hereditary hemorrhagic telangiectasia/avastin. The Laryngoscope, 120: 432–435. doi: 10.1002/lary.20757

Author Information

  1. 1

    Department of Head and Neck Surgery, San Diego School of Medicine, University of California, and the VA San Diego Healthcare System, San Diego, California, U.S.A.

  2. 2

    Department of Opthalmology, Children's Mercy Hospitals and Clinics, Kansas City School of Medicine, University of Missouri, Missouri, U.S.A.

  3. 3

    Department of Otolaryngology, University of Kansas School of Medicine, Kansas City, Missouri, U.S.A.

*Head and Neck Surgery (112C), 3350 La Jolla Village Drive, San Diego, CA 92161

Publication History

  1. Issue published online: 20 JAN 2010
  2. Article first published online: 8 DEC 2009
  3. Manuscript Accepted: 17 SEP 2009

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Keywords:

  • Hereditary hemorrhagic telangiectasia;
  • epistaxis;
  • endothelial growth factors;
  • vascular endothelial growth factors;
  • vascular endothelial growth factor inhibitors;
  • bevacizumab;
  • Avastin

Abstract

This is the first scientific report of hereditary hemorrhagic telangiectasia (HHT) epistaxis treatment by intranasal spraying of the vascular endothelial growth factor (VEGF) inhibitor bevacizumab (Avastin). Epistaxis in patients with HHT is a morbid, mortal condition that is difficult and unpleasant to manage. Nasal telangiectasia growth is modulated by VEGF, which is elevated in HHT patients. Bevacizumab is a VEGF inhibitor that diminishes epistaxis when administered intravenously or injected locally, or as reported here when sprayed topically onto the nasal mucosa. Laryngoscope, 2010

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