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Multimodality bronchoscopic imaging of recurrent respiratory papillomatosis

Authors

  • Henri G. Colt MD,

    Corresponding author
    1. Pulmonary and Critical Care Medicine, Department of Medicine, University of California School of Medicine, Irvine, California, U.S.A
    • UCI Medical Center, 101 The City Drive South, Bldg. 53, Rm. 119, Rt. 81, Orange, CA 92868
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  • Septimiu D. Murgu MD,

    1. Pulmonary and Critical Care Medicine, Department of Medicine, University of California School of Medicine, Irvine, California, U.S.A
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  • Bockhyun Jung MD,

    1. Department of Internal Medicine, Pulmonary and Critical Care Medicine, University of Ulsan, Gangneung Asan Hospital, Gangneung, South Korea
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  • Yeh-Chan Ahn PhD,

    1. Beckman Laser Institute, University of California, Irvine Irvine, California, U.S.A
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  • Matt Brenner MD

    1. Pulmonary and Critical Care Medicine, Department of Medicine, University of California School of Medicine, Irvine, California, U.S.A
    2. Beckman Laser Institute, University of California, Irvine Irvine, California, U.S.A
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Abstract

Objectives/Hypothesis.

Recurrent respiratory papillomatosis (RRP) of the central airways requires removal to potentially reduce recurrence and risk for malignant transformation. Analogous to the principles of treatment for early lung cancer, a precise determination of the extent of cartilage invasion could help guide therapeutic decisions and monitor response to treatment. The purpose of this study was to determine whether a bronchoscopy platform comprised of white light bronchoscopy (WLB), endobronchial ultrasound (EBUS), and optical coherence tomography (OCT) could identify layered microstructure of RRP and underlying cartilage.

Study Design.

Case study.

Methods.

A bronchoscopy platform consisting of commercially available WLB, EBUS using a 7.5 MHz convex probe (BF-UC 160F; Olympus Optical Co. Ltd, Tokyo, Japan), and a time-domain OCT with front imaging and inside actuation (Niris Imaging System; Imalux Corp., Cleveland, OH) was used in a patient with tracheal stenosis from RRP. Findings are compared with results of histology and the characteristics of imaging modalities are discussed.

Results.

WLB revealed tracheal pedunculated lesions. EBUS showed a 1-cm hypoechogenic density corresponding to the papilloma, visualized above a hyperechogenic density corresponding to tracheal cartilage. There was no sonographic evidence of cartilage disruption or adjacent lymphadenopathy. OCT revealed a layer of heterogeneous light backscattering suggesting the mucosal papilloma, and a layer of high-degree scattering, corresponding to the central fibrovascular core noted on histology.

Conclusions.

Layered microstructures of RRP and underlying airway cartilage can be identified using a combination of acoustic and optical bronchoscopic imaging modalities with different resolution and depth of penetration characteristics. Laryngoscope, 2010

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