Pediatric Airway

Tonsillectomy in post-transplant lymphoproliferative disease in children

  1. Angela K. Sturm-O'Brien MD1,*,
  2. M. John Hicks MD, PhD, DDS2,
  3. Carla M. Giannoni MD1,
  4. Marcelle Sulek MD1,
  5. Ellen M. Friedman MD1,*

Article first published online: 3 FEB 2010

DOI: 10.1002/lary.20799

Issue

The Laryngoscope

The Laryngoscope

Volume 120, Issue 3, pages 608–611, March 2010

Additional Information

How to Cite

Sturm-O'Brien, A. K., Hicks, M. J., Giannoni, C. M., Sulek, M. and Friedman, E. M. (2010), Tonsillectomy in post-transplant lymphoproliferative disease in children. The Laryngoscope, 120: 608–611. doi: 10.1002/lary.20799

Author Information

  1. 1

    Bobby R. Alford Department of Otolaryngology–Head and Neck Surgery, Baylor College of Medicine, Houston, Texas, U.S.A.

  2. 2

    Department of Pathology, Baylor College of Medicine, Houston, Texas, U.S.A.

*Baylor College of Medicine, One Baylor Plaza NA 102, Houston, TX 77030

Publication History

  1. Issue published online: 16 FEB 2010
  2. Article first published online: 3 FEB 2010
  3. Manuscript Accepted: 4 NOV 2009

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Keywords:

  • Tonsillectomy;
  • post-transplant lymphoproliferative disease;
  • adenotonsillar hypertrophy;
  • liver transplant

Abstract

Objectives/Hypothesis:

To review the role of tonsillectomy in diagnosis and management of post-transplant lymphoproliferative disorder (PTLD).

Study Design:

Case series using a retrospective chart review.

Methods:

A retrospective review of post-transplant lymphoproliferative disease at a tertiary academic medical center from January 2004 to April 2008. Data extracted includes patients' gender, age at transplantation, year of transplantation and tonsillectomy, type of transplant, presenting symptoms, type of immunosuppression, and outcome.

Results:

Six out of 25 (24%) patients who underwent tonsillectomy were found to have PTLD. The patient's characteristics, gender, age at transplantation, year of transplantation and tonsillectomy, type of transplant, presenting symptoms, type of immunosuppression, and outcomes are discussed.

Conclusions:

In our series, tonsillar hypertrophy, male gender, young age at transplantation, and liver transplantation were associated with higher rates of PTLD. Given the devastating nature of PTLD, early detection with tonsillectomy and institution of treatment is critical. Laryngoscope, 2010

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