The authors have no other funding, financial relationships, or conflicts of interest to disclose.
Viscoelastic properties of phonosurgical biomaterials at phonatory frequencies†
Article first published online: 8 MAR 2010
Copyright © 2010 The American Laryngological, Rhinological, and Otological Society, Inc.
Volume 120, Issue 4, pages 764–768, April 2010
How to Cite
Kimura, M., Mau, T. and Chan, R. W. (2010), Viscoelastic properties of phonosurgical biomaterials at phonatory frequencies. The Laryngoscope, 120: 764–768. doi: 10.1002/lary.20816
- Issue published online: 22 MAR 2010
- Article first published online: 8 MAR 2010
- Manuscript Accepted: 2 DEC 2009
- National Institutes of Health, NIDCD. Grant Numbers: R01 DC006101, R01 DC005788
- injection laryngoplasty;
- Level of Evidence: 5.
The purpose of this study was to examine the functional biomechanical properties of several injectable biomaterials currently or potentially used for vocal fold augmentation.
Rheometric investigation of phonosurgical materials in vitro.
Linear viscoelastic shear properties of 3% bovine collagen (atelocollagen), micronized AlloDerm (Cymetra; LifeCell Corp., Branchburg, NJ), calcium hydroxylapatite (CaHA) (Radiesse; BioForm Medical, San Mateo, CA), and 2.4% cross-linked hyaluronic acid (HA) gel (Juvéderm; Allergan, Inc., Irvine, CA) were quantified as functions of frequency covering the phonatory range, and compared to those of the human vocal fold cover. Measurements of elastic shear modulus (G′) and dynamic viscosity (η′) were made at up to 250 Hz with a controlled-strain simple-shear rheometer. Linear least-squares regression was conducted to curve-fit log G′ and log η′ versus log frequency, and statistical analysis was performed with one-way analysis of variance.
Radiesse and Cymetra were found to be the stiffest and the most viscous materials, followed by Juvéderm and atelocollagen. There were significant differences in the magnitudes of G′ and η′ among the phonosurgical materials and the normal human vocal fold cover (p < .001), whereas there was no significant difference in the frequency dependence of G′ and η′ among the materials. Post hoc Tukey tests revealed significant differences (p < .05) in pairwise comparisons of the magnitudes of G′ and η′ among all materials and the vocal fold cover.
These findings suggested that although these biomaterials may be injected lateral to the lamina propria for the treatment of glottic insufficiency, none of them are rheologically optimal for the functional reconstruction of the vocal fold lamina propria. Laryngoscope, 2010