Presented at the American Academy of Otolaryngology–Head and Neck Surgery Annual Meeting and OTO EXPO, San Diego, California, U.S.A., October 7, 2009.
Head and Neck
Article first published online: 20 APR 2010
Copyright © 2010 The American Laryngological, Rhinological, and Otological Society, Inc.
Volume 120, Issue 5, pages 953–958, May 2010
How to Cite
Lee, J. K., Yoon, T. M., Seo, D. J., Sun, E. G., Bae, J. A., Lim, S. C., Choi, Y. D., Lee, J. H., Joo, Y. E. and Kim, K. K. (2010), KAI1 COOH-terminal interacting tetraspanin (KITENIN) expression in early and advanced laryngeal cancer. The Laryngoscope, 120: 953–958. doi: 10.1002/lary.20864
This study was supported by a grant CUHRICM (Chonnam National University Hospital Research Institute of Clinical Medicine)–CRI08056-1. The authors have no other funding, financial relationships, or conflicts of interest to disclose.
- Issue published online: 21 APR 2010
- Article first published online: 20 APR 2010
- Manuscript Accepted: 8 JAN 2010
- KAI1 COOH-terminal interacting tetraspanin (KITENIN);
- laryngeal neoplasms;
- Level of Evidence: 1a.
To investigate the expression of KAI1 COOH-terminal interacting tetraspanin (KITENIN) in patients with laryngeal cancers and to examine the correlation between its expression and various clinical and pathological variables.
Cross-sectional study with planned data collection.
Tumor specimens were collected from 32 patients with laryngeal squamous carcinoma (collection of consecutive 32 tumor samples; 14 early stage, 18 advanced stage). Expression of KITENIN in the tissues obtained was determined by Western blot analysis and immunohistochemical staining. The patient characteristics including age, gender, tumor location, histology, stage, tumor extent, lymph node metastasis, and survival were obtained by review of the hospital records.
KITENIN expression was significantly increased in laryngeal cancer tissues compared to adjacent normal tissue mucosa, as well as in metastatic lymph nodes compared to nonmetastatic lymph nodes. High KITENIN expression was significantly associated with advanced stage, tumor extent, and lymph node metastasis (P = .016, .016, and .005, respectively). There was no difference in the overall survival and disease-free survival between the low- and high-KITENIN expression groups among patients with laryngeal cancer.
These results suggest that KITENIN expression may be associated with tumor progression in patients with laryngeal cancer. Further studies are needed to determine whether KITENIN expression adds prognostic value to conventional factors, such as the stage and status of metastasis, in a large series with a long period of follow-up. Laryngoscope, 2010