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KAI1 COOH-terminal interacting tetraspanin (KITENIN) expression in early and advanced laryngeal cancer

Authors

  • Joon Kyoo Lee MD, PhD,

    Corresponding author
    1. Department of Otolaryngology–Head and Neck Surgery, Chonnam National University Medical School and Hwasun Hospital, Jeonnam, South Korea
    • Department of Otolaryngology–Head and Neck Surgery, Chonnam National University Medical School and Hwasun Hospital, 160 Ilsimri, Hwasuneup, Hwasungun, Jeonnam, South Korea 519-809
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  • Tae Mi Yoon MD,

    1. Department of Otolaryngology–Head and Neck Surgery, Chonnam National University Medical School and Hwasun Hospital, Jeonnam, South Korea
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  • Deok Jung Seo MD, PhD,

    1. Department of Otolaryngology–Head and Neck Surgery, Chonnam National University Medical School and Hwasun Hospital, Jeonnam, South Korea
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  • Eun Gene Sun,

    1. Medical Research Center for Gene Regulation, Chonnam National University Medical School and Hwasun Hospital, Jeonnam, South Korea
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  • Jeong A. Bae,

    1. Medical Research Center for Gene Regulation, Chonnam National University Medical School and Hwasun Hospital, Jeonnam, South Korea
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  • Sang Chul Lim MD, PhD,

    1. Department of Otolaryngology–Head and Neck Surgery, Chonnam National University Medical School and Hwasun Hospital, Jeonnam, South Korea
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  • Yoo Duk Choi MD, PhD,

    1. Department of Pathology, Chonnam National University Medical School and Hwasun Hospital, Jeonnam, South Korea
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  • Jae Hyuk Lee MD, PhD,

    1. Department of Pathology, Chonnam National University Medical School and Hwasun Hospital, Jeonnam, South Korea
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  • Young Eun Joo MD, PhD,

    1. Department of Internal Medicine, Chonnam National University Medical School and Hwasun Hospital, Jeonnam, South Korea
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  • Kyung Keun Kim MD, PhD

    1. Medical Research Center for Gene Regulation, Chonnam National University Medical School and Hwasun Hospital, Jeonnam, South Korea
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  • Presented at the American Academy of Otolaryngology–Head and Neck Surgery Annual Meeting and OTO EXPO, San Diego, California, U.S.A., October 7, 2009.

  • This study was supported by a grant CUHRICM (Chonnam National University Hospital Research Institute of Clinical Medicine)–CRI08056-1. The authors have no other funding, financial relationships, or conflicts of interest to disclose.

Abstract

Objectives/Hypothesis:

To investigate the expression of KAI1 COOH-terminal interacting tetraspanin (KITENIN) in patients with laryngeal cancers and to examine the correlation between its expression and various clinical and pathological variables.

Study Design:

Cross-sectional study with planned data collection.

Methods:

Tumor specimens were collected from 32 patients with laryngeal squamous carcinoma (collection of consecutive 32 tumor samples; 14 early stage, 18 advanced stage). Expression of KITENIN in the tissues obtained was determined by Western blot analysis and immunohistochemical staining. The patient characteristics including age, gender, tumor location, histology, stage, tumor extent, lymph node metastasis, and survival were obtained by review of the hospital records.

Results:

KITENIN expression was significantly increased in laryngeal cancer tissues compared to adjacent normal tissue mucosa, as well as in metastatic lymph nodes compared to nonmetastatic lymph nodes. High KITENIN expression was significantly associated with advanced stage, tumor extent, and lymph node metastasis (P = .016, .016, and .005, respectively). There was no difference in the overall survival and disease-free survival between the low- and high-KITENIN expression groups among patients with laryngeal cancer.

Conclusions:

These results suggest that KITENIN expression may be associated with tumor progression in patients with laryngeal cancer. Further studies are needed to determine whether KITENIN expression adds prognostic value to conventional factors, such as the stage and status of metastasis, in a large series with a long period of follow-up. Laryngoscope, 2010

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