This article has been awarded the Shirley Baron Resident Research Award, Western Section, and was presented at the Triological Society Combined Sections Meeting, Orlando, Florida, U.S.A., February 4–7, 2010.
Article first published online: 19 MAR 2010
Copyright © 2010 The American Laryngological, Rhinological, and Otological Society, Inc.
Volume 120, Issue 6, pages 1269–1273, June 2010
How to Cite
Côté, D. W. J. and Wright, E. D. (2010), Triamcinolone-impregnated nasal dressing following endoscopic sinus surgery: A randomized, double-blind, placebo-controlled study. The Laryngoscope, 120: 1269–1273. doi: 10.1002/lary.20905
Investigator-initiated study with Nasopore dressings donated by Stryker Canada. Stryker Canada had no involvement in study design, protocol, methods, or analysis. The authors have no other funding, financial relationships, or conflicts of interest to disclose.
- Issue published online: 21 MAY 2010
- Article first published online: 19 MAR 2010
- Accepted manuscript online: 19 MAR 2010 12:00AM EST
- Manuscript Accepted: 16 FEB 2010
- Manuscript Revised: 8 FEB 2010
- Manuscript Received: 7 DEC 2009
- Nasal dressing;
- Level of Evidence: 1b.
To evaluate the impact of steroid-impregnated absorbable nasal dressing on wound healing and surgical outcomes after endoscopic sinus surgery (ESS).
A prospective, randomized, double-blinded, placebo-controlled trial.
Chronic rhinosinusitis patients with polyposis who were to undergo bilateral endoscopic sinus surgery were recruited and randomized to receive triamcinolone-impregnated bioresorbable dressing (Nasopore; Stryker Canada, Hamilton, Ontario, Canada) in one nasal cavity and saline-impregnated dressing contralaterally. Postoperative healing assessments of edema, crusting, secretions, and scarring were done at postoperative days 7, 14, 28 and at 3 and 6 months using validated Lund-Kennedy and Perioperative Sinus Endoscopy (POSE) scores.
Analysis of 19 enrolled patients having completed observation shows no significant difference between the cavity scores preoperatively using both the POSE and Lund-Kennedy scores. There was, however, a statistically significant difference at day 7 and 14 in both the Lund-Kennedy (P = .04 and P = .03, respectively) and POSE scores (P = .03 and P = .001, respectively) for the treatment and control groups, and a significant difference was also detected between the groups at 3- and 6-month observations (Lund-Kennedy, P = .007 and P = .02, respectively; POSE, P = .049 and P = .01, respectively).
Data analysis suggests a significant improvement in early postoperative healing in nasal cavities receiving triamcinolone-impregnated absorbable nasal packing following ESS and is also associated with improved healing up to 6 months postoperatively.