Histological differences between the mucosa on the medial and lateral sides of the normal uncinate process

Authors

  • Wenyu She MD,

    1. Key Laboratory of Otolaryngology, Head and Neck Surgery, Ministry of Education, Beijing Institute of Otolaryngology, Beijing, China
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  • Xiaoyan Wang MD,

    1. Key Laboratory of Otolaryngology, Head and Neck Surgery, Ministry of Education, Beijing Institute of Otolaryngology, Beijing, China
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  • Demin Han MD,

    Corresponding author
    1. Key Laboratory of Otolaryngology, Head and Neck Surgery, Ministry of Education, Beijing Institute of Otolaryngology, Beijing, China
    2. Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China
    • Beijing Institute of Otolaryngology, No. 17, HouGouHuTong, DongCheng District, Beijing, 100005 China
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  • Luo Zhang MD

    Corresponding author
    1. Key Laboratory of Otolaryngology, Head and Neck Surgery, Ministry of Education, Beijing Institute of Otolaryngology, Beijing, China
    2. Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China
    • Beijing Institute of Otolaryngology, No. 17, HouGouHuTong, DongCheng District, Beijing, 100005 China
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  • The authors have no other funding, financial relationships, or conflicts of interest to disclose.

Abstract

Objectives/Hypothesis:

To determine whether histological differences exist between the medial and lateral sides of the normal mucosa of the uncinate process (UP).

Study Design:

Retrospective histological analysis.

Methods:

Twenty UPs from the nasal cavities of 17 patients with no evidence of sinus disease were harvested during endoscopic sinus surgery. The dissected mucosa was stained with hematoxylin and eosin, chromotrope 2R, alcian blue–periodic acid-Schiff, and toluidine blue.

Results:

The thickness of the nasal mucosa was significantly greater on the medial side of the UPs than on the lateral side (173 ± 72 μm vs. 157 ± 14 μm). The thickness of the basement membrane of the lamina propria of the mucosa was significantly greater on the medial side of the UPs than on the lateral side (2.8 ± 2.5 μm vs. 0.8 ± 1.0 μm). The thickness of the epithelium was greater on the lateral side than on the medial side (14 ± 3 μm vs. 12 ± 3 μm). The area of mucous glands was larger on the medial side than on the lateral side (43 ± 13 × 10−2 mm2 vs. 33 ± 12 × 10−2 mm2). Meanwhile, the number of mast cells (4.0 ± 1.2 vs. 1.8 ± 0.2) and goblet cells (23.1 ± 12.3 vs. 10.5 ± 10.2) were both found to be higher on the lateral side than on the medial side.

Conclusions:

There are histological differences between the mucosa on the medial and lateral sides of the normal UP. Laryngoscope, 2010

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