The authors have no funding, financial relationships, or conflicts of interest to disclose.
Spontaneous cerebrospinal fluid rhinorrhea: A clinical and anatomical study†
Article first published online: 17 AUG 2010
Copyright © 2010 The American Laryngological, Rhinological, and Otological Society, Inc.
Volume 120, Issue 9, pages 1724–1729, September 2010
How to Cite
Tóth, M., Selivanova, O., Schaefer, S. and Mann, W. (2010), Spontaneous cerebrospinal fluid rhinorrhea: A clinical and anatomical study. The Laryngoscope, 120: 1724–1729. doi: 10.1002/lary.20993
- Issue published online: 23 AUG 2010
- Article first published online: 17 AUG 2010
- Manuscript Accepted: 13 APR 2010
- Manuscript Received: 16 MAR 2010
- Spontaneous cerebrospinal fluid leak;
Spontaneous nasal cerebrospinal fluid (CSF) fistula represents a rare clinical entity. The possible etiology and the localization of the rhinorrhea remain an ongoing clinical challenge. The purpose of this study was to evaluate the localization of spontaneous CSF fistula and to correlate it with anatomical studies.
Retrospective clinical study, prospective anatomical study.
Twenty-nine patients with spontaneous CSF rhinorrhea were retrospectively studied, 10 males and 19 females. Ages ranged from 10 to 92 years (mean, 50 years). In addition, 48 human skulls from newborns to adults were examined for the postnatal development of the anterior and middle cranial fossa.
In our study isolated cribriform plate defects were found in four patients. The lateral lamina of the ethmoid bone showed defects in three patients. In nine patients the bony defect could be found in the region of the fovea ethmoidalis. The bony defect between the extra- and intracranial space was found in the lateral recess of the sphenoid sinus in eight patients. Five patients had special sites (e.g., supraorbital recess and frontal recess).
This study supports the theory that bony dehiscence in the lateral lamina of the ethmoid bone can be congenital and can also be spontaneously acquired later. The bony dehiscence in the lateral wall of the sphenoid sinus can only develop during pneumatization. Laryngoscope, 2010