This study was supported in part by the U.S. Department of Veterans Affairs Northwest Center of Excellence for Health Services Research and Development and by an American Academy of Otolaryngology–Head and Neck Surgery Resident Research C.O.R.E. grant.
Head and Neck
Article first published online: 2 NOV 2010
Copyright © 2010 The American Laryngological, Rhinological, and Otological Society, Inc.
Volume 121, Issue 1, pages 102–105, January 2011
How to Cite
Francis, D. O., Maynard, C., Weymuller, E. A., Reiber, G., Merati, A. L. and Yueh, B. (2011), Reevaluation of gastroesophageal reflux disease as a risk factor for laryngeal cancer. The Laryngoscope, 121: 102–105. doi: 10.1002/lary.21165
The authors have no other funding, financial relationships, or conflicts of interest to disclose.
Views expressed in this article are those of the authors and do not necessarily represent the view of the U.S. Department of Veterans Affairs or the University of Washington.
- Issue published online: 22 DEC 2010
- Article first published online: 2 NOV 2010
- Accepted manuscript online: 30 AUG 2010 10:42AM EST
- Manuscript Accepted: 4 JUN 2010
- Manuscript Revised: 29 MAY 2010
- Manuscript Received: 9 MAR 2010
- Gastroesophageal reflux disease;
- extraesophageal reflux;
- laryngeal cancer;
- reverse causality;
- Level of Evidence: 3
The relationship between gastroesophageal reflux disease (GERD) and laryngeal cancer has not been fully elucidated. This case-control study investigates whether GERD increases the odds of developing these malignancies.
Rates of GERD among cases of laryngeal cancer identified in the Veterans Health Administration outpatient care files (year 2000–2006) were compared with controls. Cases (N = 14,449) were frequency matched 1:1 with controls. Multivariate logistic regression was used to determine the association between GERD and cancer.
After adjusting for tobacco and/or alcohol use, there was no association between GERD and laryngeal cancer (adjusted odds ratio, 1.01; 95% confidence interval, 0.92-1.12, P =.780). Although an association was found when time from GERD diagnosis to malignancy was less than 3 months, it disappeared when this period was extended further.
In this population, there was no increased risk of laryngeal cancer among patients with GERD. However, in subsite analysis, a possible relationship between GERD and glottic cancer was observed. Reverse causality must be considered in future studies assessing the relationship between reflux and laryngeal cancer to limit misclassification bias. Laryngoscope, 2011