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Clinical features, health-related quality of life, and adult voice in juvenile-onset recurrent respiratory papillomatosis


  • Presented in part in abstract form at the first Meeting of the European Academy of ORL-HNS in collaboration with the European Federation of Oto-Rhino-Laryngological Societies (EUFOS), Mannheim, Germany, June 29, 2009.



To determine clinical features, health-related quality of life, and adult voice in patients with a history of juvenile-onset recurrent respiratory papillomatosis (JORRP).

Study Design:

Case-control study.


All 32 patients with JORRP treated at Helsinki University Hospital between 1975 and 1994 were invited to an outpatient visit in spring 2008, and 18 of them (56%) entered the study. Each patient had an age- and gender-matched control subject with similar smoking habits. Videolaryngostroboscopy was performed and voice quality determined by acoustic and perceptual analysis. Voice-quality characteristics of the whole patient group and the recurrence-free patients were examined separately. Subjective voice-related disability was studied with voice handicap index (VHI) and health-related quality of life with a 15D questionnaire.


Acoustic analysis showed that patients had statistically significantly higher values in percent jitter, percent shimmer, and noise-to-harmonics ratio. Perceptual analysis indicated higher scores for patients in overall grade, roughness, breathiness, and strain. Acoustic and perceptual values for recurrence-free patients (n = 14) were also significantly higher than those for their matched paired controls. No statistically significant differences emerged for handicap related to voice or to health-related quality of life. Four study patients (22%) had undergone tracheotomy, indicating severity of juvenile-onset disease.


JORRP is a risk factor for permanent laryngeal pathology and voice-disturbances in adulthood. Laryngoscope, 2011

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