The use of adalimumab for cricoarytenoid arthritis in ankylosing spondylitis—an effective therapy

Authors

  • Gauthier Desuter MD, MSc,

    Corresponding author
    1. Otolaryngology, Head and Neck Surgery Department, Voice and Swallowing clinic, Cliniques Universitaires Saint-Luc, Universite Catholique de Louvain, Brussels, Belgium
    • Otolaryngology Head and Neck Surgery Department, Voice and Swallowing Clinic, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, 10 avenue Hippocrate, 1200 Brussels, Belgium
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  • Thierry Duprez MD,

    1. Radiology Department, Cliniques Universitaires Saint-Luc, Universite Catholique de Louvain, Brussels, Belgium
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  • Caroline Huart MD,

  • Quentin Gardiner MD,

    1. Otolaryngology, Head and Neck Surgery Department, Voice and Swallowing clinic, Cliniques Universitaires Saint-Luc, Universite Catholique de Louvain, Brussels, Belgium
    2. Otolaryngology, Head and Neck Surgery Department, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom
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  • Gust Verbruggen MD, PhD

    1. Rheumatology Department, Ghent University Hospital, Ghent University, Ghent, Belgium
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  • The authors have no financial disclosures for this article. All authors deny any financial or material support for their work. Likewise, all authors deny any financial interest in any company or entity concerned by this work.

  • The authors have no conflicts of interest to declare.

Abstract

This report describes cartilaginous regeneration in a cricoarytenoid joint affected by spondyloarthropathy using tumor necrosis factor-alpha (TNF-α) blockade, monitored by magnetic resonance (MR) and computed tomography (CT) imaging. This case is interesting for several reasons. It is only the eighth case of destructive ankylosing spondylitis-related cricoarytenoid arthritis published in the English language literature. It describes, for the first time, full recovery of vocal cord mobility following TNF-α blockade. It is also the first case to be published with MR imaging demonstrating regeneration of the cricoarytenoid cartilage following treatment. This case represents a landmark in the treatment of patients presenting with destructive arthritis involving the cricoarytenoid joint.

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