Low-stage computed tomography chronic rhinosinusitis: What is the role of endoscopic sinus surgery?

Authors

  • Luke Rudmik MD,

    1. Division of Rhinology and Sinus Surgery, Oregon Sinus Center, Department of Otolaryngology–Head and Neck Surgery, Oregon Health and Science University, Portland, Oregon, U.S.A.
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    • There is no conflict of interest for Luke Rudmik, MD. Potential conflicts of interest exist as Timothy L. Smith, MD, MPH and Jess Mace, MPH, were funded by grant support from the NIH/NIDCD. Timothy L. Smith is also a consultant for Intersect and Entrigue, which provided no financial support for this investigation.

  • Jess Mace MPH,

    1. Division of Rhinology and Sinus Surgery, Oregon Sinus Center, Department of Otolaryngology–Head and Neck Surgery, Oregon Health and Science University, Portland, Oregon, U.S.A.
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    • There is no conflict of interest for Luke Rudmik, MD. Potential conflicts of interest exist as Timothy L. Smith, MD, MPH and Jess Mace, MPH, were funded by grant support from the NIH/NIDCD. Timothy L. Smith is also a consultant for Intersect and Entrigue, which provided no financial support for this investigation.

  • Timothy Smith MD, MPH

    Corresponding author
    1. Division of Rhinology and Sinus Surgery, Oregon Sinus Center, Department of Otolaryngology–Head and Neck Surgery, Oregon Health and Science University, Portland, Oregon, U.S.A.
    • Division of Rhinology and Sinus Surgery, Department of Otolaryngology–Head and Neck Surgery, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd. PV-01, Portland, OR 97239
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    • There is no conflict of interest for Luke Rudmik, MD. Potential conflicts of interest exist as Timothy L. Smith, MD, MPH and Jess Mace, MPH, were funded by grant support from the NIH/NIDCD. Timothy L. Smith is also a consultant for Intersect and Entrigue, which provided no financial support for this investigation.


  • This work was supported by grant funding from the NIH/NIDCD R01 DC005805 (PI/PD: Smith, TL). Public clinical trial registration (http://www.clinicaltrials.gov) ID: NCT00799097.

Abstract

Objectives/Hypothesis:

To measure the change in quality-of-life (QoL) after endoscopic sinus surgery (ESS) in patients with medically recalcitrant chronic rhinosinusitis (CRS) and minimally affected computed tomography (CT) scans of the paranasal sinuses.

Study Design:

Prospective, multicenter cohort study at three academic, tertiary care centers.

Methods:

A total of 778 patients with CRS were enrolled between January 2001 and April 2009 after electing ESS. For the purposes of this analysis, patients with nasal polyposis, history of prior sinus surgery, or follow-up <6 months were excluded. Final study patients were categorized as low-stage CT CRS (Lund-Mackay ≤3; n = 17) and high-stage CT CRS (Lund-Mackay >3; n = 207). Primary outcome measures included two disease-specific QoL instruments: the Rhinosinusitis Disability Index and the Chronic Sinusitis Survey.

Results:

In patients with low-stage CT CRS, a statistically significant improvement was found across all disease-specific QoL scores (all P ≤ .012), with the exception of the CSS medication usage subscale (P = .073). These QoL improvements were comparable to those in patients with high-stage CT CRS.

Conclusions:

Some patients will present with CRS that is refractory to medical therapy even though their CT demonstrates relatively minimal disease. Based on the results of this study, ESS is associated with improved QoL in patients with low-stage CT CRS and can provide significant benefit to carefully selected patients with minimally affected CT scans. Laryngoscope, 2011

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