The authors have no financial disclosures for this article.
Article first published online: 8 FEB 2011
Copyright © 2011 The American Laryngological, Rhinological, and Otological Society, Inc., Rhinological, and Otological Society, Inc.
Volume 121, Issue 4, pages 852–855, April 2011
How to Cite
Coenraad, S., Goedegebure, A., van Goudoever, J. B. and Hoeve, L. J. (2011), Risk factors for auditory neuropathy spectrum disorder in NICU infants compared to normal-hearing NICU controls. The Laryngoscope, 121: 852–855. doi: 10.1002/lary.21430
The author have no conflicts of interest to declare.
- Issue published online: 23 MAR 2011
- Article first published online: 8 FEB 2011
- Manuscript Accepted: 1 NOV 2010
- Manuscript Received: 4 AUG 2010
- Pediatric ears/otology;
- auditory neuropathy spectrum disorder;
- NICU, infant;
- risk factor;
- Level of Evidence: 3a
To evaluate independent etiologic factors associated with auditory neuropathy spectrum disorder (ANSD) in infants who have been admitted to the neonatal intensive care unit (NICU) compared to normal-hearing controls.
We included all infants (n = 9) with the ANSD profile admitted to the NICU of Sophia Children's Hospital between 2004 and 2009. Each patient was matched with four normal-hearing controls of the same gender and postconceptional age. The following possible risk factors were studied: birth weight, dysmorphic features, APGAR scores (at 1, 5, and 10 minutes), respiratory distress (IRDS), cytomegalovirus (CMV) infection, sepsis, meningitis, cerebral bleeding, hyperbilirubinemia requiring phototherapy, peak total bilirubin level, furosemide, dexamethason, vancomycin, gentamycin, and tobramycin administration.
Nine infants met the ANSD criteria in one or both ears. IRDS (P = .02), meningitis (P = .04), and vancomycin administration (P = .009) were significantly increased in infants with ANSD compared to controls.
In high-risk NICU infants IRDS, meningitis and vancomycin administration are associated with auditory neuropathy spectrum disorder. Laryngoscope, 2011