M.E. was supported by the Interdisciplinary Program in Genetics Training Grant Fellowship.
Article first published online: 14 APR 2011
Copyright © 2011 The American Laryngological, Rhinological, and Otological Society, Inc.
Volume 121, Issue 6, pages 1184–1186, June 2011
How to Cite
Ealy, M., Lynch, K. A., Meyer, N. C. and Smith, R. J.H. (2011), The prevalence of mitochondrial mutations associated with aminoglycoside-induced sensorineural hearing loss in an NICU population. The Laryngoscope, 121: 1184–1186. doi: 10.1002/lary.21778
The authors have no conflicts of iterest to disclose.
- Issue published online: 19 MAY 2011
- Article first published online: 14 APR 2011
- Manuscript Accepted: 16 FEB 2011
- Manuscript Received: 3 DEC 2010
- hearing loss;
Several mitochondrial DNA variants increase risk for developing sensorineural hearing loss following exposure to aminoglycoside antibiotics, a particular concern in the premature infant population, as many of these babies spend time in neonatal intensive care units and are treated with aminoglycosides. To determine the relative prevalence of five mitochondrial DNA variants in the 12S rRNA gene, MT-RNR1, we genotyped 703 neonatal intensive care unit patients and 1,473 individuals from the general Iowa population. We found that the aggregate frequency of these variants (∼1.8%) was comparable between populations. Although no hearing loss was detected by newborn hearing screens in the at-risk patients, these neonatal intensive care unit graduates have an increased life-time risk for developing aminoglycoside-induced deafness.