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Does mucosal remodeling in chronic rhinosinusitis result in irreversible mucosal disease?

Authors

  • Ahmed Bassiouni MBBCh,

    1. Department of Surgery, Otorhinolaryngology–Head and Neck Surgery, University of Adelaide, Adelaide, Australia
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  • Yuresh Naidoo FRACS,

    1. Department of Surgery, Otorhinolaryngology–Head and Neck Surgery, University of Adelaide, Adelaide, Australia
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  • Peter-John Wormald MD

    Corresponding author
    1. Department of Surgery, Otorhinolaryngology–Head and Neck Surgery, University of Adelaide, Adelaide, Australia
    • Department of Otolarhinolaryngology–Head and Neck Surgery, 3C, The Queen Elizabeth Hospital, 28 Woodville Road, Woodville South 5011, SA, Australia
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  • Peter-John Wormald, MD, receives royalties from Medtronic ENT for instruments designed and is a consultant for Neilmed. The authors have no other funding, financial relationships, or conflicts of interest to disclose.

  • Editor's Note: This Manuscript was accepted for publication August 24, 2011.

Abstract

Mucosal remodeling in the sinuses is a recently described phenomenon in which the mucosa undergoes potentially irreversible changes as a result of ongoing underlying inflammatory processes. Research into remodeling that occurs in the bronchial airways in asthmatic patients has led to modification of asthma treatment guidelines. However, remodeling in the sinuses has still not led to changes in current medical or surgical management of chronic rhinosinusitis. Upper airway remodeling constitutes a new area of research that poses many unanswered clinical questions and may potentially alter the management of patients with severe chronic rhinosinusitis.Laryngoscope, 122:225–229, 2012

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