The authors have no funding, financial relationships, or conflicts of interest to disclose.
Regeneration of mastoid air cells using polycaprolactone/β-tricalcium phosphate biocomposites: An experimental study†
Article first published online: 17 JAN 2012
Copyright © 2011 The American Laryngological, Rhinological, and Otological Society, Inc.
Volume 122, Issue 3, pages 660–664, March 2012
How to Cite
Jang, C. H., Cho, Y. B., Kim, J. S., Lee, H. J. and Kim, G. H. (2012), Regeneration of mastoid air cells using polycaprolactone/β-tricalcium phosphate biocomposites: An experimental study. The Laryngoscope, 122: 660–664. doi: 10.1002/lary.22503
- Issue published online: 21 FEB 2012
- Article first published online: 17 JAN 2012
- Accepted manuscript online: 6 JAN 2012 10:21AM EST
- Manuscript Accepted: 29 NOV 2011
- Manuscript Revised: 20 NOV 2011
- Manuscript Received: 14 OCT 2011
- Mastoid air cell;
- three-dimensional PCL/β-TCP;
- Level of Evidence: 1b.
The study aimed to regenerate pneumatic air cells in guinea pig bulla using three-dimenisonal (3D) biocomposite scaffolds consisting of polycaprolactone/β-tricalcium phosphate (PCL/β-TCP).
Prospective controlled study in experimental animals.
PCL/β-TCP composites were implanted into the bulla with mucosa preservation in group A (n = 10). PCL/β-TCP composites coated with collagen were implanted in group B (n = 10). After 12 weeks, the bullae were extracted and evaluated by micro-computed tomography (micro-CT) and were processed for histological analyses.
In group A, micro-CT showed a well-maintained honeycomb appearance of micropores without obstruction. Regeneration of the mucosa was noted inside the pores of the 3D scaffold. However, partial obstruction of the micropores with new bone formation was evident in group B.
Group A showed more satisfactory mucosal regeneration into the micropores. Our results indicate that the 3D scaffold may be amenable for use during mastoidectomy. Further studies for gas exchange in the regenerated mucosa are necessary.