Ying Hu, MD, and Ping-Ping Cao, MD, PhD, contributed equally to this article.
Diagnostic significance of blood eosinophil count in eosinophilic chronic rhinosinusitis with nasal polyps in Chinese adults†
Article first published online: 17 JAN 2012
Copyright © 2012 The American Laryngological, Rhinological, and Otological Society, Inc.
Volume 122, Issue 3, pages 498–503, March 2012
How to Cite
Hu, Y., Cao, P.-P., Liang, G.-T., Cui, Y.-H. and Liu, Z. (2012), Diagnostic significance of blood eosinophil count in eosinophilic chronic rhinosinusitis with nasal polyps in Chinese adults. The Laryngoscope, 122: 498–503. doi: 10.1002/lary.22507
This work was supported by the program for New Century Excellent Talents in University from the State Education Ministry (NCET-07-0326) and the National Nature Science Foundation of China (NSFC) grants 30872847 and 81020108018 to Dr. Zheng Liu. The authors have no other funding, financial relationships, or conflicts of interest to disclose.
- Issue published online: 21 FEB 2012
- Article first published online: 17 JAN 2012
- Accepted manuscript online: 6 JAN 2012 10:24AM EST
- Manuscript Accepted: 23 NOV 2011
- Manuscript Revised: 18 NOV 2011
- Manuscript Received: 24 SEP 2011
- Chronic rhinosinusitis with nasal polyps;
- clinical characteristic;
- Level of Evidence: 2b
Over half of chronic rhinosinusitis with nasal polyps (CRSwNP) patients in China show noneosinophilic inflammation. The aim of this study was to compare the clinical characteristics of eosinophilic and noneosinophilic CRSwNP and to identify the predictors of eosinophilic CRSwNP.
A retrospective study.
There were 155 CRSwNP patients enrolled in the Tongji cohort. Eosinophilic CRSwNP was diagnosed according to our previously published histologic criterion. The demographic and clinical features were compared between eosinophilic and noneosinophilic CRSwNP. Factors associated with eosinophilic CRSwNP were determined with regression analysis, and optimal cutoff points of the predictors were determined by a receiver operating characteristic curve. The optimal cutoff points of the predictors were validated in an independent group of 35 CRSwNP patients referred to as the Taizhou cohort.
A male preponderance, a higher prevalence of smoking and atopy, and higher peripheral blood eosinophil absolute count and percentage and blood IgE levels were found in eosinophilic CRSwNP compared with noneosinophilic CRSwNP. Peripheral eosinophil absolute count and percentage were independently and significantly associated with eosinophilic CRSwNP. An absolute blood eosinophil count ≥0.215 × 109/L yielded a sensitivity of 74.2% and a specificity of 86.5%, and a blood eosinophil percentage ≥3.05% yielded a sensitivity of 80.3% and a specificity of 75.3% for the diagnosis of eosinophilic CRSwNP in the Tongji cohort. The validation study in the Taizhou cohort revealed a lower sensitivity and specificity.
Eosinophilic and noneosinophilic CRSwNP displayed significant differences in certain clinical features. Peripheral blood eosinophil count could distinguish eosinophilic and noneosinophilic CRSwNP in Chinese adults.