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Early changes in apparent diffusion coefficients predict radiosensitivity of human nasopharyngeal carcinoma xenografts

Authors

  • Jianji Pan MD,

    Corresponding author
    1. Department of Radiation Oncology, Fujian Tumor Hospital, Provincial Clinical College of Fujian Medical University, Fuzhou, Fujian, China
    • Department of Radiation Oncology, Fujian Tumor Hospital, Fujian Medical University, 91 Maluding, Fuma Road, Fuzhou, Fujian 350014, China
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  • Lele Zang,

    1. Department of Radiation Oncology, Fujian Tumor Hospital, Provincial Clinical College of Fujian Medical University, Fuzhou, Fujian, China
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  • Yu Zhang,

    1. Department of Radiation Oncology, Fujian Tumor Hospital, Provincial Clinical College of Fujian Medical University, Fuzhou, Fujian, China
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  • Jinsheng Hong,

    1. Department of Radiation Oncology, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China
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  • Yiqi Yao,

    1. Department of Radiology, Fujian Tumor Hospital, Provincial Clinical College of Fujian Medical University, Fuzhou, Fujian, China
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  • Changyan Zou,

    1. Radiation Biological Laboratory, Fujian Tumor Hospital, Provincial Clinical College of Fujian Medical University, Fuzhou, Fujian, China
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  • Lurong Zhang MD, PhD,

    1. Department of Radiation Oncology, University of Florida Shands Cancer Center, Gainesville, Florida, U.S.A
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  • Yunbin Chen MD

    1. Department of Radiology, Fujian Tumor Hospital, Provincial Clinical College of Fujian Medical University, Fuzhou, Fujian, China
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  • This study was supported by a 2009 Science and Technology Major Plan Project Grant from Fujian Province, China (no. 2009 Y0013) and a 2010 National Science Foundation Grant (no. 81071826). The authors have no other funding, financial relationships, or conflicts of interest to disclose.

Abstract

Objectives/Hypothesis:

Our objective was to predict the radiosensitivity of human nasopharyngeal carcinoma xenografts in nude mice models through an examination of early changes in apparent diffusion coefficient (ADC) values.

Study Design:

Randomized.

Methods:

BALB/c-nu nude mice (n = 20) were divided into two groups that were subcutaneously injected with CNE1 or CNE2 cell lines. Xenograft volumes were measured after tumor formation, mice were scanned with a diffusion-weighted imaging sequence, and the mean ADC values were measured (ADC0). Fifteen to 20 hours after tumors received 15 Gy, mice were scanned again and ADC values (ADC1) were measured.

Results:

ADC0 and ADC1 values of the CNE1 group showed no significant difference (P = .692). The difference between the ADC0 and ADC1 values of the CNE2 group was statistically significant (P < .001). ADC0 values of the two groups exhibited no statistically significant difference (P = .204). ADC1, ADC1-0, and ΔADC of the two groups exhibited statistically significant differences (P < .001; P = .001 and .002, respectively). After irradiation, volume changes ΔV8, ΔV10, and ΔV12 of two groups were statistically different (all P < .001). Pearson correlation analysis showed ADC1-0 and ΔADC were positively correlated with ΔV8, ΔV10, and ΔV12. The cut point was found by means of a receiver operating characteristic curve, and the ΔV12 of the two redivided groups showed a statistically significant difference (P = .001).

Conclusions:

This study found that changes in ADC values correlated with volume changes after irradiation. Therefore, ADC values have the potential to predict the radiosensitivity of nasopharyngeal carcinoma xenografts. Laryngoscope, 2012

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