The study was supported by Taipei Veterans General Hospital (Grant V100C-156). The authors have no other funding, financial relationships, or conflicts of interest to disclose.
Topical corticosteroids applied with a squirt system are more effective than a nasal spray for steroid-dependent olfactory impairment†
Article first published online: 2 FEB 2012
Copyright © 2012 The American Laryngological, Rhinological, and Otological Society, Inc.
Volume 122, Issue 4, pages 747–750, April 2012
How to Cite
Shu, C.-H., Lee, P.-L., Shiao, A.-S., Chen, K.-T. and Lan, M.-Y. (2012), Topical corticosteroids applied with a squirt system are more effective than a nasal spray for steroid-dependent olfactory impairment. The Laryngoscope, 122: 747–750. doi: 10.1002/lary.23212
- Issue published online: 20 MAR 2012
- Article first published online: 2 FEB 2012
- Manuscript Accepted: 27 DEC 2011
- Manuscript Revised: 18 DEC 2011
- Manuscript Received: 26 OCT 2011
- Olfactory function;
- olfactory dysfunction;
- Sniffin' Sticks;
- Level of Evidence: 1b.
Oral corticosteroids may restore conductive olfactory dysfunction that has been defined as steroid-dependent olfactory loss, but the effect may be temporary. This study was designed to evaluate whether applying topical corticosteroids with a squirt system was more effective than using a nasal spray to maintain olfactory improvement following oral corticosteroids.
Prospective randomized trial enrolling 32 patients.
Patients were enrolled if they had suffered from olfactory dysfunction for more than 3 months, and if their composite scores of odor threshold, discrimination, and identification scores in Sniffin' Sticks olfactory tests increased by more than six points after 1 week of oral corticosteroid treatment. A total of 32 patients were enrolled and randomized into two groups. All patients were treated with topical corticosteroids for 2 months using either the spray or squirt system, respectively.
Both measured and self-rated olfactory functions after 1 and 2 months of topical corticosteroid treatment were better in the squirt group than in the spray group. However, 2 months of topical corticosteroid treatment with the squirt system only partially maintained olfactory improvement.
The application of topical corticosteroids with a squirt system was more effective than with a spray in maintaining olfactory improvement with oral corticosteroid treatment. Nevertheless, it only partially maintained the improvement so that topical corticosteroid treatment using a squirt system needs to be combined with intervals of short-term oral corticosteroids to treat steroid-dependent olfactory loss while avoiding the side effects of long-term oral corticosteroid use. Laryngoscope, 2012