The authors have no funding, financial relationships, or conflicts of interest to disclose.
The clinical application and efficacy of sodium hyaluronate–carboxymethylcellulose during tympanomastoid surgery†
Article first published online: 28 FEB 2012
Copyright © 2012 The American Laryngological, Rhinological, and Otological Society, Inc.
Volume 122, Issue 4, pages 912–915, April 2012
How to Cite
Ahn, J. H., Lim, H. W. and Hong, H.-R. (2012), The clinical application and efficacy of sodium hyaluronate–carboxymethylcellulose during tympanomastoid surgery. The Laryngoscope, 122: 912–915. doi: 10.1002/lary.23213
- Issue published online: 20 MAR 2012
- Article first published online: 28 FEB 2012
- Manuscript Accepted: 29 DEC 2011
- Manuscript Revised: 13 DEC 2011
- Manuscript Received: 25 OCT 2011
- Hyaluronic acid;
- middle ear;
- Level of Evidence: 2c.
To evaluate the anti-adhesive and anti-inflammatory effects of sodium hyaluronate–carboxymethylcellulose (HA-CMC) on postoperative hearing improvement and complications during tympanomastoid surgery.
Prospective controlled clinical trial.
We evaluated 287 patients who underwent type I tympanoplasty, with or without canal wall up mastoidectomy, between January 2007 and June 2010. Postoperative hearing and complications were compared in the 143 patients who received Gelfoam soaked with HA-CMC during myringoplasty and the 144 patients who received Gelfoam only.
There were no significant between-group differences in sex, age, and preoperative hearing status. However, average postoperative air-bone gap (13.7 ± 8.5 dB vs. 17.2 ± 9.9 dB) and the number of air-bone gaps smaller than 10 dB (40.6% vs. 24.3%) were significantly improved in the HA-CMC compared with the control group. In addition, the rates of re-otorrhea, reperforation of the tympanic membrane (TM), postoperative TM adhesion, and reoperation were lower in the HA-CMC than in the control group without significances.
These findings suggest that combined application of Gelfoam with HA-CMC may be beneficial in patients undergoing tympanomastoid surgery. Laryngoscope, 2012