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The clinical application and efficacy of sodium hyaluronate–carboxymethylcellulose during tympanomastoid surgery

Authors

  • Joong Ho Ahn MD,

    Corresponding author
    1. Department of Otolaryngology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea
    • Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-2 dong Songpa-gu, Seoul 138-736, South Korea
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  • Hyun Woo Lim MD,

    1. Department of Otolaryngology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea
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  • Hye-Ran Hong MD

    1. Department of Otolaryngology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea
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  • The authors have no funding, financial relationships, or conflicts of interest to disclose.

Abstract

Objectives/Hypothesis:

To evaluate the anti-adhesive and anti-inflammatory effects of sodium hyaluronate–carboxymethylcellulose (HA-CMC) on postoperative hearing improvement and complications during tympanomastoid surgery.

Study Design:

Prospective controlled clinical trial.

Methods:

We evaluated 287 patients who underwent type I tympanoplasty, with or without canal wall up mastoidectomy, between January 2007 and June 2010. Postoperative hearing and complications were compared in the 143 patients who received Gelfoam soaked with HA-CMC during myringoplasty and the 144 patients who received Gelfoam only.

Results:

There were no significant between-group differences in sex, age, and preoperative hearing status. However, average postoperative air-bone gap (13.7 ± 8.5 dB vs. 17.2 ± 9.9 dB) and the number of air-bone gaps smaller than 10 dB (40.6% vs. 24.3%) were significantly improved in the HA-CMC compared with the control group. In addition, the rates of re-otorrhea, reperforation of the tympanic membrane (TM), postoperative TM adhesion, and reoperation were lower in the HA-CMC than in the control group without significances.

Conclusions:

These findings suggest that combined application of Gelfoam with HA-CMC may be beneficial in patients undergoing tympanomastoid surgery. Laryngoscope, 2012

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