Presented in part at the 39th Annual Meeting of the American Society of Clinical Oncology, Chicago, Illinois, U.S.A., May 31 – June 3, 2003.
Head and Neck
Article first published online: 28 FEB 2012
Copyright © 2012 The American Laryngological, Rhinological, and Otological Society, Inc.
Volume 122, Issue 5, pages 1043–1050, May 2012
How to Cite
Sherman, E. J., Fisher, S. G., Kraus, D. H., Zelefsky, M. J., Seshan, V. E., Singh, B., Shaha, A. R., Shah, J. P., Wolf, G. T. and Pfister, D. G. (2012), TALK score: Development and validation of a prognostic model for predicting larynx preservation outcome. The Laryngoscope, 122: 1043–1050. doi: 10.1002/lary.23220
Supported in part by the Overman and Garban Intercapital Funds. The authors have no other funding, financial relationships, or conflicts of interest to disclose.
- Issue published online: 18 APR 2012
- Article first published online: 28 FEB 2012
- Manuscript Accepted: 3 JAN 2012
- Manuscript Revised: 3 DEC 2011
- Manuscript Received: 27 SEP 2011
- Laryngeal neoplasms;
- decision making;
- combined modality therapy;
- Level of Evidence: 2c.
To develop and validate a simple prognostic tool that would help predict larynx preservation outcome.
A retrospective review of 3 prospective studies.
We reviewed consecutive chemotherapy/radiation protocols for patients (n = 170) with advanced, resectable, squamous cell, larynx, or pharynx cancer treated at Memorial Sloan-Kettering Cancer Center from 1988 to 1995 with larynx preservation intent. The outcome was successful larynx preservation. Model validation used data from U. S. Department of Veterans Affairs larynx preservation study.
The developed model added one point for each poor prognostic covariate present (show in parentheses) and was given the acronym TALK: T stage (T4), albumin (<4 g/dL), maximum alcohol/liquor use (≥6 drinks/day or heavy drinking), and Karnofsky performance status (<80%). The 3-year larynx preservation rates by TALK score were 65% (0), 41% (1–2), and 6% (3–4), P < .0001; on validation, the TALK 3–4 group was particularly well demarcated.
The TALK score is an easily applied and valid tool that should assist treatment selection.