The authors have no funding, financial relationships, or conflicts of interest to disclose.
Impedance and extraesophageal manifestations of reflux in pediatrics†
Article first published online: 23 MAR 2012
Copyright © 2012 The American Laryngological, Rhinological, and Otological Society, Inc.
Volume 122, Issue 6, pages 1397–1400, June 2012
How to Cite
Greifer, M., Ng, K. and Levine, J. (2012), Impedance and extraesophageal manifestations of reflux in pediatrics. The Laryngoscope, 122: 1397–1400. doi: 10.1002/lary.23250
- Issue published online: 1 JUN 2012
- Article first published online: 23 MAR 2012
- Manuscript Accepted: 25 JAN 2012
- Manuscript Revised: 13 DEC 2011
- Manuscript Received: 4 OCT 2011
- Multichannel intraluminal impedance;
- extraesophageal reflux;
- gastroesophageal reflux;
- Level of Evidence: 4
Extraesophageal manifestations of gastroesophageal reflux (GER) include such signs and symptoms as cough, asthma, respiratory symptoms, hoarseness, and laryngoscopic findings. We reviewed the role of MII-pH monitoring in the evaluation of these findings in children to determine whether there is an association with pathological acid or nonacid reflux.
Retrospective chart review.
We retrospectively reviewed charts from patients who underwent MII-pH. Inclusion criteria were ages 0 to 21 years with extraesophageal signs or symptom. Data were analyzed using dedicated software and manually reviewed. Reflux composite score was calculated based on DeMeester criteria. Impedance scores were calculated based on adult criteria. Symptom indexes were calculated.
A total of 119 MII-pH studies were performed. Of those, 63 studies met inclusion criteria. There were 39 males and 24 females with mean age 7.32 ± 4.1 years. The most common indication was cough. Six children had pathological GER based on DeMeester score. Using impedance criteria, only 10 of 63 patients had an abnormal evaluation (mean reflux episodes 107). Seven patients (15.2%) were found to have an association between symptom and reflux event.
No association was demonstrated between the extraesophageal signs and symptoms and pathological GER based on DeMeester score or the number of reflux events based on impedance testing.