The authors have no other funding, financial relationships, or conflicts of interest to disclose.
Head and Neck
Clinical relevance of quality-of-life data in laryngectomized patients†
Article first published online: 27 MAR 2012
Copyright © 2012 The American Laryngological, Rhinological, and Otological Society, Inc.
Volume 122, Issue 7, pages 1532–1538, July 2012
How to Cite
Fahsl, S., Keszte, J., Boehm, A., Vogel, H.-J., Völkel, W., Meister, E. F., Oeken, J., Sandner, A., Koscielny, S., Kluge, A., Heim, M. E., Dietz, A. and Singer, S. (2012), Clinical relevance of quality-of-life data in laryngectomized patients. The Laryngoscope, 122: 1532–1538. doi: 10.1002/lary.23263
- Issue published online: 21 JUN 2012
- Article first published online: 27 MAR 2012
- Manuscript Accepted: 1 FEB 2012
- Manuscript Revised: 23 JAN 2012
- Manuscript Received: 17 NOV 2011
- German Federal Ministry for Education and Research. Grant Number: #7DZAIQTX
- Head and neck;
- quality of life;
Statistically significant differences in health-related quality of life (HRQL) are not always clinically relevant. It is also plausible that patients perceive other changes to be relevant than health professionals do. The objective of this study was to find thresholds for HRQL that laryngectomees consider to be clinically relevant 1 year after surgery, (i.e., the level of HRQL that patients rate as satisfactory). A second aim was to investigate how many laryngectomized patients reached those targets.
Multicenter cross-sectional study.
A total of 28 patients 1 year following laryngectomy and 24 healthcare professionals (HCPs) defined target values for the QLQ-C30 and QLQ-H&N35. In another sample of 157 laryngectomized patients 1 year following laryngectomy, we determined what percentage of patients reached these thresholds.
Patients are the most accepting of sensory impairments (56.5), coughing (53.6), and dyspnea (44.0), whereas constipation (9.1) and nausea/vomiting (10.7) were rated as being the most troublesome symptoms. HCPs assessed more of the studied complaints as being tolerable than patients did, especially in psychosocial domains. Between 34.5% (senses) and 86.5% (constipation) of the reference group hit the predefined targets at different scales.
Symptoms caused by disease are easier for patients to live with than more general nonspecific symptoms. Taking into account that some adverse effects of disease or therapy are partially irreversible, target values additional to changes of HRQL can be helpful when interpreting data.