This research was supported by grant funding from the National Medical Research Council of Singapore. The authors have no other funding, financial relationships, or conflicts of interest to disclose.
Version of Record online: 2 JUL 2012
Copyright © 2012 The American Laryngological, Rhinological, and Otological Society, Inc.
Volume 122, Issue 8, pages 1809–1814, August 2012
How to Cite
Lau, D. P., Chng, C. B., Choo, J. Q., Teo, N., Bunte, R. M. and Chui, C. K. (2012), Development of a microclip for laryngeal microsurgery: Initial animal studies. The Laryngoscope, 122: 1809–1814. doi: 10.1002/lary.23280
Work related to this article was presented at the 1st Congress of CEORL-HNS, Barcelona, Spain, July 2–6, 2011.
- Issue online: 25 JUL 2012
- Version of Record online: 2 JUL 2012
- Manuscript Accepted: 10 FEB 2012
- Manuscript Revised: 20 JAN 2012
- Manuscript Received: 18 SEP 2011
- wound closure;
Mucosal closure following laryngeal microsurgery can be challenging due to limited access, and incisions are often left to heal without formal closure. This study explores the hypothesis that a bioabsorbable microclip can be developed as an alternative method to close mucosal incisions in laryngeal microsurgery.
In vitro studies were performed to determine if a suitable clip could be designed using bioabsorbable materials. A porcine model was used to study behavior of the clip in vivo.
We initially studied poly-ϵ-caprolactone but encountered difficulty creating a small clip with the necessary material strength. Using magnesium we were able to produce a clip sufficiently small to close vocal fold incisions. Magnesium is biocompatible, bioabsorbable, and malleable, and has been used to manufacture vascular stents and sutures. The magnesium microclip could be deployed rapidly using modified 2-mm micro-laryngeal cup forceps, which enable the clip to close in a circular shape. In vitro and in vivo tests showed the clip held securely to the vocal fold mucosa. Macroscopic and histologic studies showed no significant injury to the contralateral vocal fold. There was no evidence of lower airway injury after implanting clips into the lower airway.
The bioabsorbable clip could be used to close selected incisions in laryngeal microsurgery. Currently we are working to further reduce the size of the clip and modify its bioabsorption properties to enable precise control of degradation.