This work was presented in part at the Digestive Disease Week 2009 and at the Eighteenth Annual Dysphagia Research Society Annual Meeting, San Diego, California, U.S.A., March 3–6, 2010.
Head and Neck
Article first published online: 7 MAY 2012
Copyright © 2012 The American Laryngological, Rhinological, and Otological Society, Inc.
Volume 122, Issue 8, pages 1719–1723, August 2012
How to Cite
Siwiec, R. M., Dua, K., Surapaneni, S. N., Hafeezullah, M., Massey, B. and Shaker, R. (2012), Unsedated transnasal endoscopy with ultrathin endoscope as a screening tool for research studies. The Laryngoscope, 122: 1719–1723. doi: 10.1002/lary.23304
This work is supported in part by NIH grants: 1P01DK068051-01A1 and 5RO1DK025731. The authors have no other funding, financial relationships, or conflicts of interest to disclose.
- Issue published online: 25 JUL 2012
- Article first published online: 7 MAY 2012
- Accepted manuscript online: 22 MAR 2012 10:19AM EST
- Manuscript Accepted: 22 FEB 2012
- Manuscript Revised: 10 FEB 2012
- Manuscript Received: 26 JAN 2012
- Transnasal endoscopy;
- unsedated endoscopy;
- ultrathin endoscope;
- gastroesophageal reflux disease;
- Barrett's esophagus;
- Level of Evidence: 4
Asymptomatic subjects volunteering for research studies are generally stratified as healthy based on a questionnaire, medical interviewing, and physical examination. The aim of this study was to evaluate the prevalence of upper gastrointestinal (GI) abnormalities in healthy asymptomatic volunteers using unsedated transnasal esophagogastroduodenoscopy (T-EGD) with an ultrathin endoscope as an additional screening tool.
A prospective study from one academic medical center with extensive experience in T-EGD.
Consecutive 150 subjects volunteering for research studies were initially screened by using a gastroesophageal reflux disease (GERD) questionnaire, interviewing, and examination. Based on these, they were stratified as healthy asymptomatic volunteers or with GERD. Unsedated T-EGD was then performed by a faculty member who was blinded to the results of the initial assessment.
On initial assessment using GERD questionnaire, medical interviewing, and physical examination, of the total 150 consecutive research volunteers, 83 (average age 33 ± 16 years; 46 females, 37 males) subjects were healthy asymptomatic volunteers and 67 (average age 36 ± 15 years; 35 females, 32 males) had symptoms of GERD. On T-EGD, GI pathology was found in 15 of 83 (18%) healthy asymptomatic volunteers as compared to 24 of 67 (36%) stratified as having GERD (P < .01). The esophageal abnormalities found in healthy asymptomatic volunteers were esophagitis (13.3%), Barrett's esophagus (2.4%), hiatus hernia (2.4%), and gastritis (2.4%).
A small but significant number of asymptomatic subjects have abnormal upper GI findings. Hence, transnasal unsedated endoscopy can be considered as a screening tool to stratify subjects as healthy, especially when considering them for research studies. Laryngoscope, 2012