Larynglogy

Epidemiological aspects of recurrent respiratory papillomatosis: A population-based study†‡

  1. Turid Omland MD1,*,
  2. Harriet Akre MD, PhD2,
  3. Mari Vårdal MSc3,
  4. Kjell Brøndbo MD, PhD1

Article first published online: 7 MAY 2012

DOI: 10.1002/lary.23327

Issue

The Laryngoscope

The Laryngoscope

Volume 122, Issue 7, pages 1595–1599, July 2012

Additional Information

How to Cite

Omland, T., Akre, H., Vårdal, M. and Brøndbo, K. (2012), Epidemiological aspects of recurrent respiratory papillomatosis: A population-based study. The Laryngoscope, 122: 1595–1599. doi: 10.1002/lary.23327

Author Information

  1. 1

    Department of Otorhinolaryngology, Head and Neck Surgery, Oslo University Hospital, Oslo, Norway

  2. 2

    Department of Otorhinolaryngology, Lovisenberg Diaconal Hospital, Oslo, Norway

  3. 3

    Department of Medical Statistics, Oslo University Hospital, Oslo, Norway

*Department of Otorhinolaryngology, Head and Neck Surgery, Oslo University Hospital, Sognsvannsv 20, N-0027 Oslo, Norway

  1. †

    This work was performed at the Department of Otorhinolaryngology and Head/Neck Surgery, Oslo University Hospital, Oslo, Norway.

  2. ‡

    The authors have no funding, financial relationships, or conflicts of interest to disclose.

Publication History

  1. Issue published online: 21 JUN 2012
  2. Article first published online: 7 MAY 2012
  3. Accepted manuscript online: 29 MAR 2012 06:17AM EST
  4. Manuscript Accepted: 5 MAR 2012
  5. Manuscript Revised: 26 JAN 2012
  6. Manuscript Received: 20 OCT 2011

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Keywords:

  • Human papillomavirus;
  • incidence;
  • adult laryngeal papillomatosis;
  • juvenile laryngeal papillomatosis;
  • Level of Evidence: 2c

Abstract

Objectives/Hypothesis:

The incidence of genital infections, cervical cancer, and oropharyngeal cancer induced by human papillomaviruses (HPV) is increasing in Western countries. Primarily, this study was conducted to estimate the incidence rate of recurrent respiratory papillomatosis (RRP) in juveniles and adults in two Norwegian subpopulations for each year between 1987 and 2009. The secondary objective of the study was to investigate whether there are trends in the incidence rates of RRP in the study period similar to what we have seen for HPV-related cancer.

Study Design:

Population-based study.

Methods:

Two Norwegian subpopulations with 2.6 million and 1.1 million inhabitants were investigated for the juvenile and adult forms of RRP, respectively, between the years of 1987 and 2009. Patients treated for RRP were identified in all ear/nose/throat departments located in the two areas.

Results:

The overall incidence rates of RRP in juveniles and adults were 0.17 (95% confidence interval [CI], 0.10–0.25) and 0.54 (95% CI, 0.44–0.65) per 100,000, respectively. We found a preponderance of males in both groups (P = .000 for adults and P = .038 for children). There was no significant change in the yearly incidence rate during the study period, for either adults or children, even when stratifying for gender in each group. The median age at onset was 4 years for children and 34 years for adults, with no significant difference between genders, nor significant changes during the study years.

Conclusions:

This study does not support our hypothesis of an increasing incidence of RRP, for either children or adults. The estimated incidence rates in the Norwegian subpopulations are consistent with former population-based studies. Male preponderance in children was an unexpected finding. Further studies are warranted. Laryngoscope, 2012

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