Effect of cisplatin on distortion product otoacoustic emissions in Japanese patients

Authors

  • Peem Eiamprapai MD,

    1. Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine , Kyoto University, Kyoto City, Kyoto, Japan
    2. Department of Otolaryngology, Faculty of Medicine, Mahasarakham University , Umpur Meung, Mahasarakham Province, Thailand
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  • Norio Yamamoto MD, PhD,

    Corresponding author
    1. Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine , Kyoto University, Kyoto City, Kyoto, Japan
    • Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto city, Kyoto 606-0815, Japan
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  • Harukazu Hiraumi MD, PhD,

    1. Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine , Kyoto University, Kyoto City, Kyoto, Japan
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  • Eriko Ogino-Nishimura MD,

    1. Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine , Kyoto University, Kyoto City, Kyoto, Japan
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  • Morimasa Kitamura MD,

    1. Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine , Kyoto University, Kyoto City, Kyoto, Japan
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  • Shigeru Hirano MD, PhD,

    1. Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine , Kyoto University, Kyoto City, Kyoto, Japan
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  • Juichi Ito MD, PhD

    1. Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine , Kyoto University, Kyoto City, Kyoto, Japan
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  • This study was supported by an International Fellowship Program from Takeda Science Foundation (P.E.), a Grant-in-Aid for Young Scientists (B) (22791595) (N.Y.), a Grant-in-Aid for Scientific Research (C) (22591907) (M.K.), a Grant-in-Aid for Scientific Research (C) (21592192) to (S.H.), and a Grant-in-Aid for Scientific Research (S) (23229009) to (J.I.) from the Ministry of Education, Culture, Sports, Science and Technology.

  • The authors have no other funding, financial relationships, or conflicts of interest to disclose.

Abstract

Objectives/Hypothesis:

Although it is well known that cisplatin is associated with ototoxicity, there is still a lack of knowledge concerning the ototoxicity of cisplatin, especially in Japanese head and neck cancer patients. The objectives of this study were to determine the incidence rate of cisplatin ototoxicity and to determine the threshold dose causing ototoxicity in the Japanese population.

Study Design:

Before-and-after study in a tertiary referral hospital.

Methods:

The distortion product otoacoustic emission (DPOAE) was measured 1 week after each administration of cisplatin in 44 Japanese head and neck cancer patients treated at Kyoto University Hospital. We determined the incidence and threshold dose of cisplatin ototoxicity according to DPOAE data.

Results:

The incidence of ototoxicity detected by DPOAE was 77.3%. The average DPOAE value was significantly lower in patients who received more than 200 mg/m2 cisplatin than the baseline DPOAE value. The threshold dose for cisplatin ototoxicity was lower in Japanese patients than in European patients.

Conclusions:

Our data suggest that Japanese patients are more susceptible to cisplatin-induced ototoxicity. This is presumably caused by a genetic difference.

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