The authors have no funding, financial relationships, or conflicts of interest to disclose.
Head and Neck
Accuracy of the current TNM classification in predicting survival in patients with sinonasal mucosal melanoma†
Article first published online: 1 MAY 2012
Copyright © 2012 The American Laryngological, Rhinological, and Otological Society, Inc.
Volume 122, Issue 8, pages 1734–1738, August 2012
How to Cite
Koivunen, P., Bäck, L., Pukkila, M., Laranne, J., Kinnunen, I., Grénman, R. and Mäkitie, A. A. (2012), Accuracy of the current TNM classification in predicting survival in patients with sinonasal mucosal melanoma. The Laryngoscope, 122: 1734–1738. doi: 10.1002/lary.23343
- Issue published online: 25 JUL 2012
- Article first published online: 1 MAY 2012
- Accepted manuscript online: 5 APR 2012 04:55AM EST
- Manuscript Accepted: 14 MAR 2012
- Manuscript Revised: 2 FEB 2012
- Manuscript Received: 20 DEC 2011
- Level of Evidence: 4
The first International Union Against Cancer (UICC) TNM classification for aerodigestive malignant mucosal melanoma was not published until 2009, and since then, only a few studies have evaluated the accuracy of this staging system. Our aim was to evaluate the accuracy of this UICC staging system for sinonasal malignant mucosal melanoma (SMMM) in a nationwide survey.
Retrospective, population-based, multicenter study.
The hospital surgical and discharge registries were used to identify the patients. A database including demographic and clinicopathologic variable was created.
Altogether, 50 SMMM patients diagnosed in Finland from 1990 to 2004 were evaluated. Three- and 5-year overall survival rates were 44% and 27%, respectively. Significant differences in overall survival according to T classification (P = .028, log rank) and stage (P = .02, log rank) were found. Tumor extension to the sphenoid sinus had a significant negative impact on survival (n = 11, P = .03, log rank).
The current UICC staging system for mucosal melanoma provides a useful format for staging SMMMs in clinical settings. Laryngoscope, 2012