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Accuracy of the current TNM classification in predicting survival in patients with sinonasal mucosal melanoma

Authors

  • Petri Koivunen MD,

    1. Department of Otorhinolaryngology–Head and Neck Surgery Oulu University Hospital, Oulu, Finland
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  • Leif Bäck MD,

    1. Department of Otorhinolaryngology–Head and Neck Surgery, Helsinki University Central Hospital, Helsinki, Finland
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  • Matti Pukkila MD,

    1. Department of Otorhinolaryngology–Head and Neck Surgery, Kuopio University Hospital, Kuopio, Finland
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  • Jussi Laranne MD,

    1. Department of Otorhinolaryngology–Head and Neck Surgery, Tampere University Hospital, Tampere, Finland
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  • Ilpo Kinnunen MD,

    1. Department of Otorhinolaryngology–Head and Neck Surgery, Turku University Hospital and University of Turku, Turku, Finland
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  • Reidar Grénman MD,

    Corresponding author
    1. Department of Otorhinolaryngology–Head and Neck Surgery, Turku University Hospital and University of Turku, Turku, Finland
    • Department of Otorhinolaryngology–Head and Neck Surgery, Turku University Hospital, P.O. Box 52, FI-20521 Turku, Finland
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  • Antti A. Mäkitie MD

    1. Department of Otorhinolaryngology–Head and Neck Surgery, Helsinki University Central Hospital, Helsinki, Finland
    2. Department of Otorhinolaryngology–Head and Neck Surgery, University of Helsinki, Helsinki, Finland
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  • The authors have no funding, financial relationships, or conflicts of interest to disclose.

Abstract

Objectives/Hypothesis:

The first International Union Against Cancer (UICC) TNM classification for aerodigestive malignant mucosal melanoma was not published until 2009, and since then, only a few studies have evaluated the accuracy of this staging system. Our aim was to evaluate the accuracy of this UICC staging system for sinonasal malignant mucosal melanoma (SMMM) in a nationwide survey.

Study Design:

Retrospective, population-based, multicenter study.

Methods:

The hospital surgical and discharge registries were used to identify the patients. A database including demographic and clinicopathologic variable was created.

Results:

Altogether, 50 SMMM patients diagnosed in Finland from 1990 to 2004 were evaluated. Three- and 5-year overall survival rates were 44% and 27%, respectively. Significant differences in overall survival according to T classification (P = .028, log rank) and stage (P = .02, log rank) were found. Tumor extension to the sphenoid sinus had a significant negative impact on survival (n = 11, P = .03, log rank).

Conclusions:

The current UICC staging system for mucosal melanoma provides a useful format for staging SMMMs in clinical settings. Laryngoscope, 2012

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