Chung-Chan Hsieh, MD, and Wen-Hung Wang, MD, PhD, contributed equally as first authors.
Head and Neck
A large-scale study of the association between biopsy results and clinical manifestations in patients with suspicion of nasopharyngeal carcinoma†
Version of Record online: 9 JUL 2012
Copyright © 2012 The American Laryngological, Rhinological, and Otological Society, Inc.
Volume 122, Issue 9, pages 1988–1993, September 2012
How to Cite
Hsieh, C.-C., Wang, W.-H., Lin, Y.-C., Weng, H.-H. and Lee, K.-F. (2012), A large-scale study of the association between biopsy results and clinical manifestations in patients with suspicion of nasopharyngeal carcinoma. The Laryngoscope, 122: 1988–1993. doi: 10.1002/lary.23432
The authors have no funding, financial relationships, or conflicts of interest to disclose.
- Issue online: 23 AUG 2012
- Version of Record online: 9 JUL 2012
- Manuscript Accepted: 24 APR 2012
- Manuscript Received: 27 MAR 2012
- Nasopharyngeal carcinoma;
- lymphoid hyperplasia;
- diagnostic capability;
- neck mass;
- Level of Evidence: 2b
This study investigated the association between the results of nasopharyngeal (NPX) biopsies and clinical manifestations in patients with suspected nasopharyngeal carcinoma (NPC).
Retrospective cohort study.
Four hundred seventy-three patients with 512 NPX biopsies were enrolled. The statistical analyses were conducted to evaluate clinical significance and screening performance for suspected NPC.
The negative rate of all NPX biopsies was 69.7% (345/495), and the majority of the noncancerous group revealed lymphoid hyperplasias (208/345, 60.3%). The three diagnostic capabilities of NPX mass, epistaxis (EPI), neck mass (NM), EPI-NM, EPI-NPX mass, NM-NPX mass, and EPI-NM-NPX mass were 0.595, 0.557, 0.735, 0.609, 0.566, 0.748, and 0.600, respectively.
Although NPX mass, EPI, and NM were significant to identify suspected NPC, the diagnostic capabilities of combining EPI, NM, and NPX were still low. A large number of noncancerous biopsy results were obtained due to lymphoid hyperplasias often being mistaken as NPC. Laryngoscope, 2012