A large-scale study of the association between biopsy results and clinical manifestations in patients with suspicion of nasopharyngeal carcinoma

Authors

  • Chung-Chan Hsieh MD,

    1. Department of Otolaryngology–Head and Neck Surgery, Chang Gung Memorial Hospital at Chiayi and Chang Gung University College of Medicine, Chiayi, Taiwan
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    • Chung-Chan Hsieh, MD, and Wen-Hung Wang, MD, PhD, contributed equally as first authors.

  • Wen-Hung Wang MD, PhD,

    Corresponding author
    1. Department of Otolaryngology–Head and Neck Surgery, Chang Gung Memorial Hospital at Chiayi and Chang Gung University College of Medicine, Chiayi, Taiwan
    • Department of Otolaryngology–Head and Neck Surgery, Chang Gung Memorial Hospital at Chiayi and College of Medicine, Chang Gung University, 6 West Sec, Chia-Pu Road, Pu-Tzu City, Chiayi County 613, Taiwan
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  • Yen-Chun Lin MD,

    1. Department of Otolaryngology–Head and Neck Surgery, Chang Gung Memorial Hospital at Chiayi and Chang Gung University College of Medicine, Chiayi, Taiwan
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    • Chung-Chan Hsieh, MD, and Wen-Hung Wang, MD, PhD, contributed equally as first authors.

  • Hsu-Huei Weng MD, PhD,

    1. Department of Diagnostic Radiology, Chang Gung Memorial Hospital at Chiayi and Chang Gung University College of Medicine, Chiayi, Taiwan
    2. Department of Respiratory Care, Chang Gung Institute of Technology, Taoyuan, Taiwan
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  • Kam-Fai Lee MD

    1. Department of Pathology, Chang Gung Memorial Hospital at Chiayi and Chang Gung University College of Medicine, Chiayi, Taiwan
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  • The authors have no funding, financial relationships, or conflicts of interest to disclose.

Abstract

Objectives/Hypothesis:

This study investigated the association between the results of nasopharyngeal (NPX) biopsies and clinical manifestations in patients with suspected nasopharyngeal carcinoma (NPC).

Study Design:

Retrospective cohort study.

Methods:

Four hundred seventy-three patients with 512 NPX biopsies were enrolled. The statistical analyses were conducted to evaluate clinical significance and screening performance for suspected NPC.

Results:

The negative rate of all NPX biopsies was 69.7% (345/495), and the majority of the noncancerous group revealed lymphoid hyperplasias (208/345, 60.3%). The three diagnostic capabilities of NPX mass, epistaxis (EPI), neck mass (NM), EPI-NM, EPI-NPX mass, NM-NPX mass, and EPI-NM-NPX mass were 0.595, 0.557, 0.735, 0.609, 0.566, 0.748, and 0.600, respectively.

Conclusions:

Although NPX mass, EPI, and NM were significant to identify suspected NPC, the diagnostic capabilities of combining EPI, NM, and NPX were still low. A large number of noncancerous biopsy results were obtained due to lymphoid hyperplasias often being mistaken as NPC. Laryngoscope, 2012

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