Primary embryonal rhabdomyosarcoma of the anterior neck and thyroid

Report of a new case with review of the literature

Authors

  • Mainak Dutta MS,

    Corresponding author
    • Department of Otorhinolaryngology and Head–Neck Surgery, R. G. Kar Medical College and Hospital, Kolkata, India
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  • Indranil Chatterjee MS, DNB, MCh,

    1. Department of Pediatric Surgery, R. G. Kar Medical College and Hospital, Kolkata, India
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  • Soham Roy MD, FACS, FAAP,

    1. Department of Pediatric Otolaryngology—Head and Neck Surgery, University of Texas Medical School at Houston, Houston, Texas, U.S.A
    2. Department of Pediatric Otolaryngology, Children's Memorial Hermann Hospital, Memorial Hermann-Texas Medical Center, Houston, Texas, U.S.A
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  • Prasanta Kumar Gure MS

    1. Department of Otorhinolaryngology and Head-Neck Surgery, R. G. Kar Medical College and Hospital, Kolkata, India
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  • Presented as a poster in the Annual Meeting of the American Society of Pediatric Otolaryngology (ASPO) at the Combined Otolaryngology Spring Meetings (COSM), San Diego, California, U.S.A., April 18–22, 2012. Available at: http://www.researchposters.com/COSM/cosm2012/2-035.pdf

  • The authors have no funding, financial relationships, or conflicts of interest to disclose.

Send correspondence to Mainak Dutta, MS, Department of Otorhinolaryngology and Head-Neck surgery, Medical College and Hospital, Kolkata, 88, College Street, Kolkata 700073, West Bengal, India. E-mail: duttamainak@yahoo.com

Abstract

Primary embryonal rhabdomyosarcoma of anterior neck involving the thyroid is extremely rare. This report is only the second of its kind that describes this form of nonorbital nonparameningeal rhabdomyosarcoma in a 7-year-old boy and adds to a new, seldom-reported variant of rhabdomyosarcoma in the head-neck region. The child presented with a huge anterior neck swelling that clinically resembled a thyroid mass. Computed tomography scan showed a heterogeneous mass in the anterior neck replacing the entire right lobe of thyroid. Fine-needle aspiration cytology was nondiagnostic. Right hemithyroidectomy with selective neck dissection suggested embryonal rhabdomyosarcoma by histopathology; the diagnosis was confirmed by positive reactions to desmin and myogenin. The child was subsequently treated with chemotherapy. Repeat chemotherapy with radiotherapy was required when recurrences were detected in the mediastinum and cervical lymph nodes at 13-month follow-up.

Laryngoscope, 123:2072–2076, 2013

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