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Double-blind randomized trial on the efficacy of the Gufoni maneuver for treatment of lateral canal BPPV


  • The authors have no funding, financial relationships, or conflicts of interest to disclose.

Send correspondence to Marco Mandalà, MD, Dipartimento di Scienze neurologiche e sensoriali, Università di Siena, Viale Bracci, 11 53100, Siena, Italy. E-mail:



The need for class I and II studies on the efficacy of liberatory maneuvers in the treatment of lateral canal benign paroxysmal positional vertigo (LC-BPPV) motivated the present double-blind randomized trial on the short-term efficacy of the Gufoni liberatory maneuver (GLM).

Study Design

Double-blind randomized controlled trial.


Seventy-two patients with unilateral LC-BPPV were recruited for a multicentric study. Patients were randomly assigned to treatment by GLM (n = 37) or sham treatment (n = 35). Subjects were followed up twice (at 1 hour and 24 hours) with the supine roll test by blinded examiners.


At 1- and 24-hour follow-up, 75.7% and 83.8% of patients, respectively, undergoing GLM had recovered from vertigo, compared to around 10% of patients undergoing the sham maneuver (P < 0.0001).


To the best of our knowledge, this is the first class I study on the efficacy of the GLM in the treatment of LC-BPPV in both geotropic and apogeotropic forms. GLM proved highly effective compared to the sham maneuver (P < 0.0001). The present class I study of the efficacy of the GLM changes the level of recommendation of the method for treating LC-BPPV from level U to level B for the geotropic variant and from level B to level A for the apogeotropic variant of LC-BPPV.

Level of Evidence

1b. Laryngoscope, 2013

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