The authors have no funding, financial relationships, or conflicts of interest to disclose. The authors have no funding, financial relationships, or conflicts of interest to disclose.
Immunohistochemical detection of SATB1 is independent of thyroid cancer differentiation
Version of Record online: 13 MAY 2013
Copyright © 2013 The American Laryngological, Rhinological and Otological Society, Inc.
Volume 123, Issue 11, pages 2909–2912, November 2013
How to Cite
Murono, S., Tsuji, A., Endo, K., Kondo, S., Wakisaka, N. and Yoshizaki, T. (2013), Immunohistochemical detection of SATB1 is independent of thyroid cancer differentiation. The Laryngoscope, 123: 2909–2912. doi: 10.1002/lary.23992
- Issue online: 28 OCT 2013
- Version of Record online: 13 MAY 2013
- Manuscript Accepted: 25 DEC 2012
- thyroid cancer;
The association of special AT-rich binding protein 1 (SATB1) with a poor prognosis in various cancers has been reported. However, this association is controversial. SATB1 expression in aggressive types of thyroid cancer has not been reported to date.
SATB1 expression was immunohistochemically investigated in 35 papillary thyroid cancers, one follicular thyroid cancer, six poorly differentiated thyroid cancers, and two anaplastic thyroid cancers.
SATB1 expression was observed in none of two anaplastic thyroid cancers, one of six poorly differentiated thyroid cancers, and nine of 36 well-differentiated thyroid cancers. SATB1 expression was not significantly associated with any high-risk group-related clinicopathologic factors in well-differentiated thyroid cancer. Survival was not associated with SATB1 expression.
SATB1 expression is independent of thyroid cancer differentiation, as well as high-risk-related factors. SATB1 may not play a role in the aggressiveness of thyroid cancer.
Level of Evidence
N/A Laryngoscope, 123:2909–2912, 2013