This study was supported in part by the St. Louis Children's Foundation/Children's Surgical Services. The authors have no other funding, financial relationships, or conflicts of interest to disclose.
Evaluating a prediction model for infant hearing loss
Article first published online: 5 APR 2013
Copyright © 2013 The American Laryngological, Rhinological and Otological Society, Inc.
Volume 123, Issue 11, pages 2873–2879, November 2013
How to Cite
Lieu, J. E. C., Ratnaraj, F. and Ead, B. (2013), Evaluating a prediction model for infant hearing loss. The Laryngoscope, 123: 2873–2879. doi: 10.1002/lary.24033
- Issue published online: 28 OCT 2013
- Article first published online: 5 APR 2013
- Manuscript Accepted: 14 JAN 2013
- Manuscript Revised: 13 DEC 2012
- Manuscript Received: 25 SEP 2012
- Hearing loss;
- risk factors;
- newborn hearing screening;
- auditory brainstem response
The objective of this study was to determine whether a prognostic model using risk factors for hearing loss could predict the chance that infants who failed a newborn hearing screen would subsequently be found to have hearing loss diagnosed by auditory brainstem response testing.
Individual retrospective case-control study.
We studied 229 infants with hearing loss compared with 458 infants with normal hearing. All infants had undergone natural sleep or sedated auditory brainstem response, predominantly for not passing a newborn hearing screen. Risk factors, birth history, and other information were extracted via medical record review. Multiple logistic regression analyses identified independent predictors of hearing loss.
Four risk factors were independently predictive of hearing loss diagnosed by sleep or sedated auditory brainstem response: prematurity, 5-minute APGAR score ≤ 6, intracranial complication, and craniofacial abnormality. A prognostic model developed from these risk factors was associated with a 15% rate of hearing loss in stage I, 52% rate of hearing loss in stage II, and 96% rate of hearing loss in stage III.
The presence of any one of four independently predictive risk factors in infants who did not pass newborn hearing screen was associated with a 50% rate of hearing loss; having three or more was associated with a 90% rate of hearing loss. Knowing that an infant is at high risk of hearing loss can motivate parents to follow up with diagnostic auditory brainstem response testing so that early identification can lead to early intervention.
Level of Evidence
2b. Laryngoscope, 123:2873–2879, 2013