Presented at the 40th Annual Meeting of the Society for Ear, Nose, and Throat Advances in Children in Charleston, SC, on November 30, 2012.
Ototoxicity of olive oil in a chinchilla animal model
Article first published online: 24 APR 2013
© 2013 The American Laryngological, Rhinological and Otological Society, Inc.
Volume 123, Issue 8, pages 2009–2012, August 2013
How to Cite
Emami, N. and Daniel, S. J. (2013), Ototoxicity of olive oil in a chinchilla animal model. The Laryngoscope, 123: 2009–2012. doi: 10.1002/lary.24041
This work was supported by grants from the Fonds de la Recherche en Santeé du Quebec (FRSQ). Daniel was a speaker for Abbott and was on an advisory panel for Merck. The authors have no other funding, financial relationships, or conflicts of interest to disclose.
- Issue published online: 19 JUL 2013
- Article first published online: 24 APR 2013
- Manuscript Accepted: 15 JAN 2013
- Manuscript Revised: 9 DEC 2012
- Manuscript Received: 6 NOV 2012
- Olive oil;
- hearing loss;
- animal model;
- ear wax
Olive oil is often used by patients to soften ear wax or to relieve ear canal obstruction. It is also sold in drugstores as a cerumenolytic. To date, no study has assessed the safety of ototopical olive oil on hearing in the presence of tympanic membrane perforation. The present study aimed to assess the safety of ototopic olive oil on hearing in the presence of tympanic membrane perforation.
Prospective, randomized, controlled trial in a chinchilla animal model.
Materials and methods
Eleven chinchillas underwent bilateral myringotomy. In each animal, one ear was randomly assigned to receive olive oil (experimental ear), while the contralateral control ear received normal saline. Auditory brain response (ABR) test was performed at baseline and then 7, 14, and 30 days following the application.
At 30 days follow-up, there was no significant change in auditory brain response thresholds at 8, 16, 20, or 25 kHz. Scanning electron microscope imaging showed no damage to the hair cells.
Olive oil does not seem to cause hearing loss in chinchillas with perforated tympanic membranes. Future clinical studies are required.
Level of Evidence
N/A Laryngoscope, 123:2009–2012, 2013