Editor»s Note: This Manuscript was accepted for publication January 22, 2013.The authors have no funding, financial relationships, or conflicts of interest to disclose.
Technical modifications and functional outcomes
Article first published online: 11 MAR 2013
Copyright © 2013 The American Laryngological, Rhinological and Otological Society, Inc.
Volume 123, Issue 10, pages 2502–2508, October 2013
How to Cite
Farwell, D. G., Birchall, M. A., Macchiarini, P., Luu, Q. C., de Mattos, A. M., Gallay, B. J., Perez, R. V., Grow, M. P., Ramsamooj, R., Salgado, M. D., Brodie, H. A. and Belafsky, P. C. (2013), Laryngotracheal transplantation. The Laryngoscope, 123: 2502–2508. doi: 10.1002/lary.24053
- Issue published online: 23 SEP 2013
- Article first published online: 11 MAR 2013
- Manuscript Accepted: 22 JAN 2013
- Manuscript Revised: 19 DEC 2012
- Manuscript Received: 21 AUG 2012
- larynx transplant;
- laryngotracheal transplant;
- airway reconstruction;
- larynx stenosis;
- tracheal stenosis;
- composite tissue allotransplantation
Laryngeal transplantation offers the potential for patients without a larynx to recover their voice, which is critical in our communication age. We report clinical and functional outcomes from a laryngotracheal transplant. Widespread adoption of this technique has been slowed due to the ethical concerns of life-long immunosuppression after a nonvital organ transplant. Our patient was already on immunosuppressive medication from prior kidney–pancreas transplantation, and therefore was not exposed to added long-term risk. We describe the unique technical advances, clinical course, and rehabilitation of this patient and the implications for future laryngeal transplantation.
A laryngotracheal transplantation was performed in a 51-year-old prior kidney–pancreas transplant recipient presenting with complete laryngotracheal stenosis. Surgical modifications were made in the previously described technique related to retrieval, vascular supply, and reinnervation. This resulted in a robustly vascularized organ with well-perfused long-segment tracheal transplant and early return of motor reinnervation.
A multidisciplinary approach resulted in a successful transplant without evidence of rejection to date. Postoperatively, the patient continues to rely on a tracheotomy but has had the return of an oral and nasal airway, vocalization, smell, and taste, all experienced for the first time in 11 years.
We have demonstrated that our methods may result in a successful laryngotracheal transplant. We describe the preparation, surgical technique, rehabilitation, and interventions employed in achieving optimal outcomes. This report contributes valuable information on this rarely performed composite transplant. Laryngoscope, 123:2502–2508, 2013